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  4. Xanthan gum

Xanthan gum 通过氢键与明胶 (HY-Y1365) 相互作用，从而提高水凝胶的黏度和稳定性，同时促进细胞生长并创造有利于细胞分化的微环境[1][2]。Xanthan gum 通过增加 TNF-α、IL-6 和 IL-10 的水平来诱导促炎反应。Xanthan gum 可用于炎症和免疫学研究。

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Xanthan gum

Xanthan gum Chemical Structure

CAS No. : 11138-66-2

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Xanthan gum 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Xanthan gum interacts with gelatin (HY-Y1365) via hydrogen bonds, thereby increasing the viscosity and stability of the hydrogel while promoting cell growth and creating a microenvironment conducive to cell differentiation[1][2]. Xanthan gum induces pro-inflammatory responses by increasing the levels of TNF-α, IL-6, and IL-10. Xanthan gum can be used for inflammation and immunology research[3].

体外研究
(In Vitro)

Xanthan gum (3%, 0-28 天) 具有良好的生物相容性，可通过提高人骨髓间充质干细胞 (hMSCs) 的代谢活性而不损害细胞活力来证明[1]。
Xanthan gum (1.2 %, 2 天) 在 2.5Gel3 和 3Gel4 水凝胶中在 37°C 水化后仍能保持约 95% 的水分[2]。
Xanthan gum (1.2%, 0-24 小时) 在 2.5Gel3 和 3Gel4 水凝胶中，其溶胀率在 3 小时达到峰值，并在 24 小时内保持稳定。经 0.3% (v/v) 戊二醛交联 1-3 小时后，水凝胶的形态变化极小[2]。
Xanthan gum (1.2%, 0-10 天) 在 2.5Gel3 和 3Gel4 水凝胶中，其水解曲线在 10 天达到峰值，相应的孔隙率约为 65% 和 ~30%[2]。
Xanthan gum (1.2%, 0-14 天) 在 2.5Gel3 和 3Gel4 水凝胶中可促进共培养的人皮肤成纤维细胞和角质形成细胞的生长，表现为细胞数量在第 1 天至第 7 天显著增加，并在第 14 天进一步增加[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Xanthan gum 相关抗体:

Cell Viability Assay[1]

Cell Line: hMSCs
Concentration: 3%
Incubation Time: Day 0, Day 1, Day 4, Day 7
Result: Showed decreased viability at Day 1, while the overall viability after Day 4 of the hydrogel system is over 90%, demonstrating cytocompatibility of the proposed hydrogel with gum.

Cell Proliferation Assay[1]

Cell Line: hMSCs
Concentration: 3%
Incubation Time: Day 0, Day 3, Day 7, Day 14, Day 21, Day 28
Result: Showed a significant increase in cell metabolic activity from Day 0 to Day 3, which stabilized over the longer term of more than one week.
体内研究
(In Vivo)

Xanthan gum (185 mg/100 g，口服，每日一次，从 5 周龄持续至 15 周龄) 可增加脂肪组织中的促炎细胞因子，但不影响接种 Walker 256 细胞的大鼠的肿瘤发展[3]。
​ Xanthan gum (5%，口服，持续饲喂) 可促进瑞士韦伯斯特小鼠肠道微生物群中 R.UCG13 和 B. intestinalis 的扩增[4]。
​ Xanthan gum (5%，口服，从第 0 天到第 23 天) 可在抗生素治疗期间维持小鼠的肠道菌群，限制或抑制 C. difficile 的定植[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (5 weeks old, consumed xanthan gum for 8 weeks) subcutaneously injected with Walker 256 tumor cells[3]
Dosage: 185 mg/100 g mixed in diet
Administration: p.o., daily from 5 to 15 weeks of age
Result: Increased IL-6, TNF-α, and IL-10 in retroperitoneal adipose tissue.
​ Did not affect the development of Walker 256 tumors in rats.
​ Showed no significant changes in body weight, total dietary intake, tissue weights or fat and protein contents of the carcasses in rats.
Animal Model: Female Swiss Webster mice[4]
Dosage: 5%
Administration: p.o., continuous feeding
Result: Promoted the expansion of the primary degrader R.UCG13.
Supported the colonization of an introduced Bacteroides intestinalis strain, enabling it to outcompete the endogenous strain.
Enabled the expansion of B. intestinalis via oligosaccharides released by R.UCG13.
Removal from the diet reduced R.UCG13 abundance, confirming its role in sustaining this bacterium.
Animal Model: C57BL/6 mice (6-8 weeks olds) infected with C. difficile[5]
Dosage: 5%
Administration: p.o., form day 0 to day 23
Result: ​Maintained both diversity and overall abundance of microbes in the gut during Cefoperazone (HY-B0210) administration.
Resulted in a shift in bacterial metabolism marked by significantly higher butyrate and propionate concentrations in mice compared to those on standard chow.
Disrupted 48 of the 112 OTUs that were negatively correlated with Cefoperazone treatment in the standard chow group.
​ Partially protected the microbiota from the effects of Cefoperazone, and preserved colonization resistance to C. difficile.
Led to a significant reduction in C. difficile colonization levels by day15, compared to standard chow, in the antibiotic cocktail model (Kanamycin (HY-16566​), Gentamicin (HY-A0276A​), Colistin (HY-A0089​), Metronidazole (HY-B0318​), and Vancomycin (HY-B0671​)​).
CAS 号
性状

固体

颜色

White to off-white

中文名称

黄原胶
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

H2O 中的溶解度 : 2.5 mg/mL (超声助溶)

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动物溶解方案计算器
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纯度 & 产品资料

COA (278 KB)

产品使用指南 (1538 KB)
参考文献

Xanthan gum 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Xanthan gum11138-66-2黄原胶Biochemical Assay Reagentspro-inflammatory factorscytokinesthickening agentpolysaccharidehuman microbiomesinterfacexanthan gumdietgut microbiotadietary fiberhydrocolloidIL-6food chaincoconut proteininteractionRuminococcaceaeBacteroides intestinalisemulsion stabilizationIL-10drug deliverystabilizerTNF-αrheological propertiesadipose tissueWalker 256 tumor cellstumor developmentInhibitorinhibitorinhibit

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