2. Stem Cell/Wnt
  3. YAP
  4. YAP-IN-1

YAP-IN-1 (Compound (+)-1) 是一种靶向 YAP1 的自噬 (Autophagy) 抑制剂。YAP-IN-1 对 Hippo 通路转录因子 YAP1 的 Kd 为 9.13 μM，可诱导 YAP1 通过伴侣介导自噬 (CMA) 途径降解，从而抑制 Rab7 介导的自噬体与溶酶体融合过程，并下调自噬水平，而不影响溶酶体功能。YAP-IN-1 有望用于癌症 (如肝癌、乳腺癌等) 领域的研究。

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YAP-IN-1 Chemical Structure

YAP-IN-1 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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YAP-IN-1 相关抗体

Top Publications Citing Use of Products

查看 YAP 亚型特异性产品:

查看所有亚型
YAP/TAZ YAP/TAZ-TEAD TEAD

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

YAP-IN-1 (Compound (+)-1) is an autophagy (Autophagy) inhibitor targeting YAP1. YAP-IN-1 binds to the Hippo pathway transcription factor YAP1 with a Kd of 9.13 μM and induces its degradation via the chaperone-mediated autophagy (CMA) pathway. This process inhibits Rab7-mediated fusion of autophagosomes and lysosomes, thereby reducing overall autophagy levels without affecting lysosomal function. YAP-IN-1 holds promise for research in cancer (e.g., liver cancer, breast cancer, etc.)[1].

分子量

336.49

Formula

C21H24N2S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

YAP-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YAP-IN-1YAPYes-associated proteinInhibitorinhibitorinhibit

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目录号：
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