2. Antibody-drug Conjugate/ADC Related Apoptosis
  3. Antibody-Drug Conjugates (ADCs) Apoptosis
  4. Zilovertamab vedotin

Zilovertamab vedotin  (Synonyms: VLS-101; MK-2140)

目录号: HY-P99956 纯度: 98.15%
COA

摩尔计算器

Zilovertamab vedotin (VLS-101) 是一种新型抗体-活性分子偶联物 (ADC)，包含人源化单克隆抗体 zilovertamab 和抗微管细胞毒素单甲基 vedotin。Zilovertamab vedotin 与肿瘤细胞 ROR1 结合导致快速内化、转运至溶酶体、抗体-活性分子偶联物裂解和单甲基 vedotin 释放。Zilovertamab vedotin 诱导细胞凋亡。Zilovertamab vedotin 可用于癌症研究。

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Zilovertamab vedotin Chemical Structure

Zilovertamab vedotin Chemical Structure

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规格 价格 是否有货 数量
1 mg ￥7800
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Zilovertamab vedotin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Zilovertamab vedotin (VLS-101) is a novel antibody-drug conjugate comprising the humanized monoclonal antibody zilovertamab and and the anti-microtubule cytotoxin monomethyl vedotin. Zilovertamab vedotin binding to tumor cell ROR1 results in rapid internalization, trafficking to lysosomes, antibody–agent conjugate cleavage, and monomethyl vedotin release. Zilovertamab vedotin induces apoptosis. Zilovertamab vedotin can be used in research of cancer[1].

体外研究
(In Vitro)

Zilovertamab vedotin (VLS-101; 0-100 μg/mL) 以剂量依赖方式诱导 ROR1+ 原代 MCL 细胞的细胞毒性[1]。
Zilovertamab vedotin (24h; ibrutinib 敏感 (JeKo-1) 和耐药 (JeKo BTK kd2) 细胞株) 诱导细胞凋亡和细胞周期阻滞在 G2/M 期[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Zilovertamab vedotin 相关抗体:
体内研究
(In Vivo)

Zilovertamab vedotin (VLS-101; 2.5 mg/kg; i.v.; 每周，持续3周) 靶向表达 ROR1 且对 ibrutinib 和 CAR T 双重耐药的 PDX 模型。Zilovertamab vedotin 抑制肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NSG PDX mice models with dual resistance to ibrutinib and CAR T. A PDX model[1]
Dosage: 2.5 mg/kg
Administration: intravenous injection; weekly, for 3 weeks
Result: Eliminated subcutaneous tumor growth of BA-resistant PDX model (PDX-1).
Prolonged tumor bearing mouse survival.
Clinical Trial
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Zilovertamab vedotin 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zilovertamab vedotinVLS-101 MK-2140VLS101VLS 101MK2140MK 2140MK-2140Antibody-Drug Conjugates (ADCs)ApoptosisAntibody-Drug ConjugatesZilovertamabanti-microtubule cytotoxin monomethylcancerprimary MCL cellsInhibitorinhibitorinhibit

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