1. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  2. EGFR
  3. ZNL-0056

ZNL-0056 是一种具有口服活性的 ATP 竞争性 抑制剂,靶向 EGFR ATP 结合位点中的 Cys797 和 Cys775。ZNL-0056 选择性抑制 H3255 细胞中的 EGFR 及其下游信号传导。ZNL-0056 可用于癌症的研究。

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ZNL-0056 Chemical Structure

ZNL-0056 Chemical Structure

CAS No. : 2767987-38-0

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ZNL-0056 is an orally active ATP-competitive inhibitor that targets both the Cys797 and Cys775 in the ATP binding site of EGFR. ZNL-0056 selectively inhibits EGFR and its downstream signaling in H3255 cells. ZNL-0056 can be used for the research of cancer[1].

体内研究
(In Vivo)


药代动力学分析[1]

Route Dose (mg/kg) T1/2 (h) Tmax (h) Cmax (ng/mL) AUClast (ng·min/mL) AUCINF_obs (ng·min/mL) AUC%Extrap (ng·min/mL) Clobs (mL·min/kg) MRTINF_obs (h) F (%)
i.v. 1 0.33 0.08 965 21820 22013 0.86 53.6 0.30 /
i.p. 3 0.49 0.19 611 27398 27482 0.39 142.9 / 41.9
p.o. 10 3.8 0.14 658 53219 63341 15.7 158.8 / 24.4

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

477.58

Formula

C25H27N5O3S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
ZNL-0056
目录号:
HY-160564
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