2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. Zuclomiphene

Zuclomiphene 是 Clomiphene citrate (HY-B0463) 中的顺式异构体。Zuclomiphene 具有口服活性且有抗雌激素作用。Zuclomiphene 可以降低胆固醇水平。枸橼酸 zuclomiphene 可用于内分泌学和代谢性疾病的研究。

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Zuclomiphene

Zuclomiphene Chemical Structure

CAS No. : 15690-55-8

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Zuclomiphene 的其他形式现货产品:

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Zuclomiphene 相关抗体

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Zuclomiphene is a cis isomer of Clomiphene citrate (HY-B0463). Zuclomiphene is orally active and has an antiestrogenic effect. Zuclomiphene can reduce cholesterol levels. Zuclomiphene can be for the researches of endocrinology and metabolic disease[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HT-1080 IC50
37.86 μM
Compound: 76
Inhibition of IDH1 R132H mutant in human HT-1080 cells assessed as suppression of 2-HG production incubated for 48 hrs by LC-MS analysis
Inhibition of IDH1 R132H mutant in human HT-1080 cells assessed as suppression of 2-HG production incubated for 48 hrs by LC-MS analysis
[PMID: 29847930]
体内研究
(In Vivo)

Zuclomiphene (4-40 mg/kg，灌胃，每日一次，连续 90 天) 会降低雄性小鼠的睾丸相对重量[1]。
Zuclomiphene (30 mg/kg，腹腔注射，每周两次) 会降低大鼠的胆固醇含量[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male mice[1]
Dosage: 4 and 40 mg/kg
Administration: Orally gavage
Result: Reduced leydig cells surrounding the tubules in size and numbers.
Showed testicular degeneration and an absence of sperm in the seminiferous tubules.
Reduced kidney weights and body weight.
Reduced levels of LH, FSH and testosterone.
分子量

405.96

Formula

C26H28ClNO
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Zuclomiphene 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zuclomiphene15690-55-8Estrogen Receptor/ERRAntiestrogenicCholesterolERREndocrinologyMetabolicInhibitorinhibitorinhibit

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目录号：
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