2. Metabolic Enzyme/Protease
  3. Glucosidase
  4. α-Glucosidase-IN-15

α-Glucosidase-IN-15 (Compound 14B) 是一种有效的、具有口服活性的 α-glucosidase 抑制剂，IC50 为 3.34 μM。α-Glucosidase-IN-15 具有抗糖尿病活性。

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α-Glucosidase-IN-15 Chemical Structure

α-Glucosidase-IN-15 Chemical Structure

CAS No. : 2820424-85-7

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α-Glucosidase-IN-15 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

α-Glucosidase-IN-15 (Compound 14B) is a potent, orally active α-glucosidase inhibitor with an IC50 of 3.34 μM. α-Glucosidase-IN-15 shows antidiabetic activity[1].

IC50 & Target

IC50: 3.34 μM (α-glucosidase)[1]
体内研究
(In Vivo)

α-Glucosidase-IN-15 (Compound 14B) (10 and 20 mg/kg; p.o.; b.w. for 4 weeks) shows antidiabetic activity in Streptozocin (HY-13753)-induced diabetic rats[1].
α-Glucosidase-IN-15 (10 and 20 mg/kg; p.o.; once) significantly decreases the serum glucose level after the administration of glucose (3 g/kg, oral) in rats[1].
α-Glucosidase-IN-15 (2000mg/kg; p.o.; b.w. for 2 weeks) demonstrates no mortality in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar albino rats (170–200 g), Streptozotocin-induced diabetes model[1]
Dosage: 10 and 20 mg/kg
Administration: Oral administration, b.w. for 4 weeks
Result: Decreased the level of blood glucose, reversed Streptozocin-induced body weight loss. Showed antihyperlipidemic effects on Streptozotocin-induced diabetes, reduced to a significant level of serum biomarkers.
分子量

372.53

Formula

C24H24N2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

α-Glucosidase-IN-15 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Glucosidase-IN-152820424-85-7Glucosidasediabetesorally activeanti-hyperglycemicInhibitorinhibitorinhibit

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目录号：
HY-151135
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