2. Metabolic Enzyme/Protease Apoptosis PI3K/Akt/mTOR
  3. Drug Metabolite Bcl-2 Family Akt Apoptosis
  4. 15(S)-HPETE

15(S)-HPETE 是 15(S)-HETE (HY-113336) 前体。15(S)-HPETE 是 Arachidonic acid (HY-109590) 在 15-脂氧合酶途径中形成的产物。15(S)-HPETE 降低 Bcl-2 蛋白、Akt 蛋白及磷酸化 Akt 蛋白水平。15(S)-HPETE 诱导凋亡 (Apoptosis)。15(S)-HPETE 拮抗 15 (S)-HETE 的促血管生成作用。15(S)-HPETE 对慢性粒细胞白血病具有抗肿瘤作用。15(S)-HPETE 可用于脂肪组织外植体研究。

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15(S)-HPETE

15(S)-HPETE Chemical Structure

CAS No. : 70981-96-3

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规格 价格 是否有货 数量
25 μg (297.20 µM * 250 μL in Ethanol) ￥882
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15(S)-HPETE 相关抗体

Top Publications Citing Use of Products

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3

查看 Akt 亚型特异性产品:

查看所有亚型
Akt Akt1 Akt2 Akt3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

15(S)-HPETE is a precursor of 15(S)-HETE (HY-113336). 15(S)-HPETE is a product of Arachidonic acid (HY-109590) in the 15-lipoxygenase pathway. 15(S)-HPETE reduces Bcl-2, Akt, and phosphorylated Akt protein levels. 15(S)-HPETE induces Apoptosis. 15(S)-HPETE antagonizes the angiogenic effects of 15(S)-HETE. 15(S)-HPETE exhibits antitumor effects against chronic myeloid leukemia. 15(S)-HPETE can be used in adipose tissue explant studies[1][2][3].

体外研究
(In Vitro)

15(S)-HPETE (0.1 μM; 24 h) 在 HUVEC 中逆转 15(S)-HETE 的促血管生成作用，减少 CD31 和 VEGF 产生[1]。
15 (S)-HPETE (0.1 μM) 显著抑制大鼠附睾脂肪组织外植体内皮细胞出芽[2]。
15 (S)-HPETE (1-20 μM；3-24 h) 可抑制 K-562 细胞 (慢性粒细胞白血病细胞) 活力，诱导其凋亡[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

15(S)-HPETE 相关抗体:

Western Blot Analysis[2]

Cell Line: Adipose-derived endothelial cells (isolated from rat epididymal fat pads)
Concentration: 0.1 μM
Incubation Time: 48 h
Result: Showed a decrease in Bcl-2 protein level with no change in Bax level.
Showed a reduction in Akt protein level and its phosphorylation level.
分子量

336.47

Formula

C20H32O4
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Solution, -20°C, 2 years
纯度 & 产品资料

纯度: 97.3%

COA (276 KB)

产品使用指南 (1538 KB)
参考文献

15(S)-HPETE 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

15(S)-HPETE70981-96-3Drug MetaboliteBcl-2 FamilyAktApoptosisPKBProtein kinase BHUVECendothelial celladipose tissueK-562anti-angiogenicInhibitorinhibitorinhibit

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目录号：
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