1. Metabolic Enzyme/Protease
    Immunology/Inflammation
  2. Endogenous Metabolite
    STING
  3. 2',3'-cGAMP

2',3'-cGAMP (Synonyms: 2'-3'-cyclic GMP-AMP)

目录号: HY-100564
产品使用指南

2',3'-cGAMP (2'-3'-cyclic GMP-AMP) 是一种哺乳动物细胞中的内源性 cGAMP 分子,其含有两个不同的磷酸二酯键,一个位于 GMP 的 2'-OH 和 AMP 的 5'-磷酸之间,另一个位于 AMP 的 3'-OH 和GMP 的 5'-磷酸之间。2',3'-cGAMP 是在哺乳动物细胞中为响应细胞质中的 DNA 而产生并以高亲和力结合STING,是干扰素-β (IFNβ) 的有效诱导物。

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2',3'-cGAMP Chemical Structure

2',3'-cGAMP Chemical Structure

CAS No. : 1441190-66-4

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Description

2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a molecule in endogenous cGAMP mammalian cells which contains two distinct phosphodiester linkages, one between 2′-OH of GMP and 5′-phosphate of AMP, and the other between 3′-OH of AMP and 5′-phosphate of GMP. 2',3'-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm and binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ)[1].

IC50 & Target[1]

Human Endogenous Metabolite

 

Molecular Weight

674.41

Formula

C₂₀H₂₄N₁₀O₁₃P₂

CAS No.

1441190-66-4

SMILES

OC1([H])[C@](OP(O)(OC[C@](O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@@H]4O)([H])[C@@]4([H])O5)=O)([H])[C@H](N6C(NC(N)=NC7=O)=C7N=C6)O[C@]1([H])COP5(O)=O

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This equation is commonly abbreviated as: C1V1 = C2V2

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产品名称:
2',3'-cGAMP
目录号:
HY-100564
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2',3'-cGAMP

Cat. No.: HY-100564