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  3. 3-Deazaadenosine hydrochloride

3-Deazaadenosine hydrochloride 

目录号: HY-W013332A 纯度: 99.44%
COA 产品使用指南

3-Deazaadenosine (hydrochloride) 是一种 S-腺苷高半胱氨酸水解酶 (S-adenosylhomocysteine hydrolase) 抑制剂,Ki 值为 3.9 µM;3-Deazaadenosine (hydrochloride) 具有抗炎、抗增殖、抗 HIV 等活性。

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3-Deazaadenosine hydrochloride Chemical Structure

3-Deazaadenosine hydrochloride Chemical Structure

CAS No. : 86583-19-9

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥2597
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1 mg ¥1713
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5 mg ¥3900
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10 mg ¥5388
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25 mg ¥8621
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Customer Review

Other Forms of 3-Deazaadenosine hydrochloride:

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Top Publications Citing Use of Products

    3-Deazaadenosine hydrochloride purchased from MCE. Usage Cited in: Arch Toxicol. 2021 Jan;95(1):299-309.  [Abstract]

    After treating with 3-Deazaadenosine (DAA, 50 mM), the global methylation inhibitor, EJ and J82 cell lines show decreased m6A modifcation level and reduced SOD2 expression level.
    • 生物活性

    • 实验参考方法

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    3-Deazaadenosine (hydrochloride) is an inhibitor of S-adenosylhomocysteine hydrolase, with a Ki of 3.9 µM; 3-Deazaadenosine has anti-inflammatory, anti-proliferative and anti-HIV activity.

    IC50 & Target

    HIV-1

     

    体外研究
    (In Vitro)

    3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine hydrolase, with a Ki of 3.9 μM. 3-Deazaadenosine shows anti-HIV effect, and inhibits p24 antigen in peripheral blood mononuclear (PBMCs) cells infected with HIV-1 isolates (A012 and A018) with IC50s of 0.15 and 0.20 μM, respectively[1].
    3-Deazaadenosine (1-100 μM) inhibits LPS-induced expression of TNF-α mRNA, increases DNA binding activity of NF-κB, and causes proteolytic degradation of IκBα, but Not IκBβ in RAW 264.7 cells. 3-Deazaadenosine (100 μM) enhances nuclear translocation of NF-κB, but blocks LPS-induced NF-κB transcriptional activity, and such inhibition is augmented by the addition of homocysteine[2]. 3-Deazaadenosine (50, 100 μM) dose-dependently inhibits the phosphorylation of Raf and ERK, protein-dependent kinase 1, protein kinase B (Akt), and forkhead transcription factor FoxO1a. 3-Deazaadenosine (50 μM) suppresses vascular smooth muscle cell (VSMC) proliferation via interfering with Ras signaling[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    分子量

    302.71

    Formula

    C11H15ClN4O4

    CAS 号
    性状

    固体

    颜色

    White to off-white

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)

    溶解性数据
    In Vitro: 

    H2O 中的溶解度 : ≥ 100 mg/mL (330.35 mM)

    DMSO 中的溶解度 : 41.67 mg/mL (137.66 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

    * "≥" means soluble, but saturation unknown.

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 3.3035 mL 16.5175 mL 33.0349 mL
    5 mM 0.6607 mL 3.3035 mL 6.6070 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

    * 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息:

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    由于实验过程有损耗,建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    该产品水溶性佳,请具体参考实测 水 / PBS / Saline 中的溶解度数据。
    您所需的储备液浓度超过该产品的实测溶解度,如有需要,请与 MCE 中国技术支持联系。
    纯度 & 产品资料

    纯度: 99.44%

    参考文献
    Cell Assay
    [1]

    The HIV-1 strains A012 and A018 are used in the assay. Inhibition of p24 antigen is measured. Briefly, PHA-stimulated peripheral blood mononuclear (PBMCs) are incubated with either HIV-1 strain for 1 h at 37°C at 200-fold the 50% tissue culture infectious dose (TCID50) of the virus stock per 2 × 105 PBMC cells. The TCID50 is defined as the amount of virus stock at which 50% of the inoculated wells are positive. Cells are then grown in microtiter plates with different drug concentrations at 2 × 105 cells per well. On day 4, cells are resuspended and split 1:3 with fresh media and 3-Deazaadenosine. Supernatant p24 antigen is determined on day 7 by ELISA[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    参考文献

    3-Deazaadenosine hydrochloride 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 3.3035 mL 16.5175 mL 33.0349 mL 82.5873 mL
    5 mM 0.6607 mL 3.3035 mL 6.6070 mL 16.5175 mL
    10 mM 0.3303 mL 1.6517 mL 3.3035 mL 8.2587 mL
    15 mM 0.2202 mL 1.1012 mL 2.2023 mL 5.5058 mL
    20 mM 0.1652 mL 0.8259 mL 1.6517 mL 4.1294 mL
    25 mM 0.1321 mL 0.6607 mL 1.3214 mL 3.3035 mL
    30 mM 0.1101 mL 0.5506 mL 1.1012 mL 2.7529 mL
    40 mM 0.0826 mL 0.4129 mL 0.8259 mL 2.0647 mL
    50 mM 0.0661 mL 0.3303 mL 0.6607 mL 1.6517 mL
    60 mM 0.0551 mL 0.2753 mL 0.5506 mL 1.3765 mL
    80 mM 0.0413 mL 0.2065 mL 0.4129 mL 1.0323 mL
    100 mM 0.0330 mL 0.1652 mL 0.3303 mL 0.8259 mL

    * 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    产品名称:
    3-Deazaadenosine hydrochloride
    目录号:
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