2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. CDD0102

CDD0102 是一种有效的 M1 毒蕈碱 (Muscarinic) 受体激动剂。

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CDD0102 Chemical Structure

CDD0102 Chemical Structure

CAS No. : 146422-58-4

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CDD0102 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

CDD0102 is a potent M1 Muscarinic receptor agonist.

IC50 & Target

mAChR[1]
体外研究
(In Vitro)

CDD0102 (CDD-0102) is an efficacious muscarinic agonist in cell lines expressing M1 receptors. CDD0102 displays much lower activity at M3 and M5 receptors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CDD0102 相关抗体:
体内研究
(In Vivo)

After i.p. injections, CDD0102 (CDD-0102) crosses the blood-brain barrier (BBB) in a dose-dependent manner. In toxicological studies, the LD50 of CDD0102 is 190 mg/kg following i.p. injections and greater than 1,000 mg/kg following oral administration. In follow-up studies, after oral administration at a dose of 10 mg/kg, CDD0102 fully reverses memory deficits associated with IgG-192 saporin administration. Again, no side effects are observed at this dose[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

180.21

Formula

C8H12N4O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献
Cell Assay
[1]

A9 L cells expressing muscarinic receptor subtypes are cultured. Biochemical studies examine the ability of compounds (e.g., CDD0102, 0.01 nM, 0.1 nM, 1 nM, 10 nM, 100 nM, 1 μM, 10 μM, 100 μM and 1 mM) to stimulate relevant biochemical responses through muscarinic receptors expressed in A9 Lcells. Assays of PI metabolism provides a measure of in vitro activity associated with M1, M3, and M5 receptor activation, while inhibition of adenylyl cyclase activity determined efficacy at M2 and M4 receptors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[1]

Mice[1]
Young, male CF-1 mice are administered CDD0102 or xanomeline by either p.o. or i.p. injection with doses from 1 to 1,000 mg/kg by each route, and monitored for 24 h. Animals are observed daily for 1 wk for appearance of delayed toxicity. A second set of animals is treated with a narrow range of concentrations based on the preliminary studies to determine the LD50.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

CDD0102 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDD0102146422-58-4CDD0102ACDD 0102CDD-0102mAChRMuscarinic acetylcholine receptorInhibitorinhibitorinhibit

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CDD0102
目录号：
HY-U00230
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