2. GPCR/G Protein MAPK/ERK Pathway Metabolic Enzyme/Protease
  3. Ras Phosphodiesterase (PDE)
  4. Deltarasin hydrochloride

Deltarasin hydrochloride 能抑制 KRAS 与 PDEδ 相互作用，与 PDEδ 结合的 Kd 为 41 nM。

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Deltarasin hydrochloride Chemical Structure

Deltarasin hydrochloride Chemical Structure

CAS No. : 1613404-76-4

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥2358
In-stock
2 mg ￥1116
In-stock
5 mg ￥1674
In-stock
10 mg ￥2511
In-stock
50 mg ￥8277
In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Other Forms of Deltarasin hydrochloride:

Deltarasin hydrochloride 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 2 篇科研文献

查看 Ras 亚型特异性产品:

查看所有亚型
K-Ras H-Ras Ras

查看 Phosphodiesterase (PDE) 亚型特异性产品:

查看所有亚型
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Deltarasin hydrochloride is an inhibitor of KRAS-PDEδinteraction with Kd of 38 nM for binding to purified PDEδ.

IC50 & Target

Kd: 38 nM (PDEδ)
体外研究
(In Vitro)

In liver cells, deltarasin inhibits the interaction of RAS with PDEδ with KD of 41 nM. Inhibition of PDEδ-KRAS interaction by deltarasin suppresses proliferation of human pancreatic ductal adenocarcinoma cells that are dependent on oncogenic KRAS[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Deltarasin hydrochloride 相关抗体:
体内研究
(In Vivo)

Deltarasin (10 mg/kg, i.p.) impairs dose-dependent tumor growth in nude mice bearing subcutaneous human Panc-Tu-I tumour cell xenografts[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

640.22

Formula

C40H38ClN5O
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : ≥ 52 mg/mL (81.22 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

H2O 中的溶解度 : 50 mg/mL (78.10 mM; 超声助溶)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5620 mL 7.8098 mL 15.6196 mL
5 mM 0.3124 mL 1.5620 mL 3.1239 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献
Kinase Assay
[1]

KD values are measured by fluorescence polarization measurements. For direct titrations, increasing amounts of PDEδ are added to a solution containing 50-100 nM labelled small molecule in 200 µL PBS buffer. For displacement titrations, increasing amounts of the small molecules in DMSO are directly added to fluorescein-labelled atorvastatin (24 nM) and His6-tagged PDEδ (40 nM) in 200 µL PBS-buffer (containing 0.05% CHAPS, 1% DMSO), keeping the concentration of fluorescein-labelled atorvastatin, PDEδ and DMSO constant. For KD measurements using isothermal titration calorimetry, PDEδ protein (280 µM) is titrated to small molecule (30 µM) in Tris/HCl buffer (temperature 25°C). In the Tm shift assays, protein melting points are detected by circular dichroism spectroscopy in the presence of small molecules.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Deltarasin hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 1.5620 mL 7.8098 mL 15.6196 mL 39.0491 mL
5 mM 0.3124 mL 1.5620 mL 3.1239 mL 7.8098 mL
10 mM 0.1562 mL 0.7810 mL 1.5620 mL 3.9049 mL
15 mM 0.1041 mL 0.5207 mL 1.0413 mL 2.6033 mL
20 mM 0.0781 mL 0.3905 mL 0.7810 mL 1.9525 mL
25 mM 0.0625 mL 0.3124 mL 0.6248 mL 1.5620 mL
30 mM 0.0521 mL 0.2603 mL 0.5207 mL 1.3016 mL
40 mM 0.0390 mL 0.1952 mL 0.3905 mL 0.9762 mL
50 mM 0.0312 mL 0.1562 mL 0.3124 mL 0.7810 mL
60 mM 0.0260 mL 0.1302 mL 0.2603 mL 0.6508 mL
DMSO 80 mM 0.0195 mL 0.0976 mL 0.1952 mL 0.4881 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Deltarasin1613404-76-4RasPhosphodiesterase (PDE)Inhibitorinhibitorinhibit

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产品名称：
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目录号：
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