2. Metabolic Enzyme/Protease
  3. γ-Glutamyl Transferase (GGT)
  4. GGsTop

GGsTop (Nahlsgen) 是一种有效、无毒、高度选择性和不可逆的 γ-谷酰基转肽酶 (GGT) 抑制剂，对人 GGT 的 Ki 值为 170 μM。GGsTop 的 pKa 值为 9.71，对 E.coli GGT 和人 GGT 的 Kon 值分别为 150 和 51 M-1 s-1。在大鼠缺血再灌注损伤模型中，GGsTop 具有保护肝脏功能。

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GGsTop Chemical Structure

GGsTop Chemical Structure

CAS No. : 926281-37-0

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规格 价格 是否有货 数量
1 mg ￥727
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5 mg ￥1600
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10 mg ￥2500
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25 mg ￥5600
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Other Forms of GGsTop:

GGsTop 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GGsTop (Nahlsgen) is a potent, non-toxic, highly selective and irreversible γ-GGT inhibitor, with a Ki of 170 μM for Human GGT. GGsTop shows a pKa of 9.71, also exhibits Kons of 150 and 51 M-1 s-1 against E.coli GGT and human GGT, respectively. GGsTop protects hepatic ischemia-reperfusion injury in rat model[1][2][3].

IC50 & Target

Ki: 170 μM (Human GGT)[1]
体外研究
(In Vitro)

GGsTop (Nahlsgen; Compound 5a) is a potent, highly selective and irreversible γ glutamyl transpeptidase (GGT) inhibitor, with a Ki of 170 μM for Human GGT[1]. GGsTop shows pKa of 9.71, also exhibits Kons of 150±10 and 51±3 M-1 s-1 against E.coli GGT and human GGT, respectively[1][2].
GGsTop is non-toxic compound, completely inhibits WT human GGT in 1 min at 1 mM, but less potent against the K562S mutant[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GGsTop 相关抗体:
体内研究
(In Vivo)

GGsTop (1 mg/kg) lowers levels of ALT, AST, γ-GT at 12, 24, and 48 h after ischemia-reperfusion in rats[3].
GGsTop also reduces 4-HNE and TNF-α production, and decreases hepatic necrosis in rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male rats (9 week old)[3]
Dosage: 1 mg/kg
Administration: Injected into the inferior vena cava for 12, 24, 48 h
Result: Lowered the serum levels of ALT, AST, prevented the increase of serum γ-GT levels in IR-GGsTop group.
分子量

331.26

同用名

Nahlsgen

Formula

C13H18NO7P
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

GGsTop 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GGsTop926281-37-0Nahlsgenγ-Glutamyl Transferase (GGT)γ-Glutamyl Transferase, Gamma-Glutamyl TransferaseInhibitorinhibitorinhibit

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目录号：
HY-108467
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