2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. GV-196771A

GV-196771A 是 GV196771 的钠盐形式。是 NMDA 受体拮抗剂。

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GV-196771A Chemical Structure

GV-196771A Chemical Structure

CAS No. : 166974-23-8

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GV-196771A 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

GV-196771A is the sodium salt form of GV196771, is an NMDA receptor antagonist.

IC50 & Target

NMDA receptor[1]
体内研究
(In Vivo)

GV196771 is a potent antagonist of the modulatory glycine site of the N-methyl-D-aspartate receptor. GV196771 is a potent antagonist of the modulatory glycine site of the NMDA receptor developed for treatment of neuropathic pain. GV196771 is an NMDA receptor antagonist with low oral bioavailability in rats and mice. GV196771 has low oral bioavailability (<10%) and plasma clearance (~2 mL/min/kg) in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

423.22

Formula

C20H13Cl2N2NaO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献
Animal Administration
[1]

Mice[1]
Male wild-type FVB mdr1a/1b+/+ and Pgp-deficient knockout FVBmdr1a/1b-/- mice (20-30 g) are used. Dose solutions of 0.2 mg/mL for GV196771 and 5.0 mg/mL for GF120918 are prepared fresh using 0.5% hydroxypropylmethylcellulose and 1% Tween 80 as a vehicle. Two hours before the administration of GV196771, the animals are divided into two groups. One group receive a single oral dose (10 mL/kg) of vehicle and the second group receive a single 50 mg/kg oral dose (10 mL/kg) of GF120918. Two hours later, all animals receive a single 2 mg/kg oral dose (10 mL/kg) of GV196771. At scheduled time points, mice are anesthetized with CO2 and blood samples are obtained by cardiac puncture. Blood is centrifuged to yield plasma. The MDR genotype of each animal is confirmed by a polymerase chain reaction assay after study completion.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

GV-196771A 相关分类

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Keywords:

GV-196771A166974-23-8iGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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