2. Cell Cycle/DNA Damage
  3. CDK
  4. IIIM-290

IIIM-290是有效，可口服的 CDK 抑制剂，对CDK2/A和CDK9/T1的IC50分别为90和94 nM。

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IIIM-290

IIIM-290 Chemical Structure

CAS No. : 2213468-64-3

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IIIM-290 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IIIM-290 is a potent and oral CDK inhibitor with IC50s of 90 and 94 nM for CDK2/A and CDK9/T1.

IC50 & Target[1]

CDK2/A

90 nM (IC50)

CDK9/T1

94 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
786-0 GI50
6 μM
Compound: 11d
Growth inhibition of human 786-0 cells after 48 hrs by MTT assay
Growth inhibition of human 786-0 cells after 48 hrs by MTT assay
[PMID: 29370702]
A-431 GI50
8 μM
Compound: 11d
Growth inhibition of human A431 cells after 48 hrs by MTT assay
Growth inhibition of human A431 cells after 48 hrs by MTT assay
[PMID: 29370702]
A549 GI50
4 μM
Compound: 11d
Growth inhibition of human A549 cells after 48 hrs by MTT assay
Growth inhibition of human A549 cells after 48 hrs by MTT assay
[PMID: 29370702]
BT-549 GI50
5 μM
Compound: 11d
Growth inhibition of human BT549 cells after 48 hrs by MTT assay
Growth inhibition of human BT549 cells after 48 hrs by MTT assay
[PMID: 29370702]
COLO 205 GI50
7 μM
Compound: 11d
Growth inhibition of human COLO205 cells after 48 hrs by MTT assay
Growth inhibition of human COLO205 cells after 48 hrs by MTT assay
[PMID: 29370702]
Caco-2 GI50
7 μM
Compound: 11d
Growth inhibition of human Caco2 cells after 48 hrs by MTT assay
Growth inhibition of human Caco2 cells after 48 hrs by MTT assay
[PMID: 29370702]
DU-145 GI50
5 μM
Compound: 11d
Growth inhibition of human DU145 cells after 48 hrs by MTT assay
Growth inhibition of human DU145 cells after 48 hrs by MTT assay
[PMID: 29370702]
HCT-116 GI50
5 μM
Compound: 11d
Growth inhibition of human HCT116 cells after 48 hrs by MTT assay
Growth inhibition of human HCT116 cells after 48 hrs by MTT assay
[PMID: 29370702]
HCT-116 GI50
9.32 μM
Compound: 1e; IIIM-290
Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
[PMID: 37302342]
HEK293 GI50
22 μM
Compound: 11d
Growth inhibition of human HEK293 cells after 48 hrs by MTT assay
Growth inhibition of human HEK293 cells after 48 hrs by MTT assay
[PMID: 29370702]
HEK293 GI50
> 100 μM
Compound: 1e; IIIM-290
Antiproliferative activity against HEK293 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Antiproliferative activity against HEK293 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
[PMID: 37302342]
HEK293 IC50
> 50 μM
Compound: 11d
Inhibition of [3H]-astemizole binding to human ERG expressed in HEK293 cell membranes by scintillation counting method
Inhibition of [3H]-astemizole binding to human ERG expressed in HEK293 cell membranes by scintillation counting method
[PMID: 29370702]
HL-60 GI50
0.9 μM
Compound: 11d
Growth inhibition of human HL60 cells after 48 hrs by MTT assay
Growth inhibition of human HL60 cells after 48 hrs by MTT assay
[PMID: 29370702]
HOP-62 GI50
7 μM
Compound: 11d
Growth inhibition of human HOP62 cells after 48 hrs by MTT assay
Growth inhibition of human HOP62 cells after 48 hrs by MTT assay
[PMID: 29370702]
HOP-92 GI50
3 μM
Compound: 11d
Growth inhibition of human HOP92 cells after 48 hrs by MTT assay
Growth inhibition of human HOP92 cells after 48 hrs by MTT assay
[PMID: 29370702]
LOX IMVI GI50
4 μM
Compound: 11d
Growth inhibition of human LOXIMVI cells after 48 hrs by MTT assay
Growth inhibition of human LOXIMVI cells after 48 hrs by MTT assay
[PMID: 29370702]
MCF7 GI50
4 μM
Compound: 11d
Growth inhibition of human MCF7 cells after 48 hrs by MTT assay
Growth inhibition of human MCF7 cells after 48 hrs by MTT assay
[PMID: 29370702]
MDA-MB-231 GI50
4 μM
Compound: 11d
Growth inhibition of human MDA-MB-231 cells after 48 hrs by MTT assay
Growth inhibition of human MDA-MB-231 cells after 48 hrs by MTT assay
[PMID: 29370702]
MDA-MB-468 GI50
4 μM
Compound: 11d
Growth inhibition of human MDA-MB-468 cells after 48 hrs by MTT assay
Growth inhibition of human MDA-MB-468 cells after 48 hrs by MTT assay
[PMID: 29370702]
MIA PaCa-2 GI50
1 μM
Compound: 11d
Growth inhibition of human MIAPaCa2 cells after 48 hrs by MTT assay
Growth inhibition of human MIAPaCa2 cells after 48 hrs by MTT assay
[PMID: 29370702]
MIA PaCa-2 GI50
1.94 μM
Compound: 1e; IIIM-290
Antiproliferative activity against human MIA PaCa-2 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Antiproliferative activity against human MIA PaCa-2 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
[PMID: 37302342]
MOLT-4 GI50
0.5 μM
Compound: 11d
Growth inhibition of human MOLT4 cells after 48 hrs by MTT assay
Growth inhibition of human MOLT4 cells after 48 hrs by MTT assay
[PMID: 29370702]
NCI-H226 GI50
4 μM
Compound: 11d
Growth inhibition of human NCI-H226 cells after 48 hrs by MTT assay
Growth inhibition of human NCI-H226 cells after 48 hrs by MTT assay
[PMID: 29370702]
NCI-H522 GI50
5 μM
Compound: 11d
Growth inhibition of human NCI-H522 cells after 48 hrs by MTT assay
Growth inhibition of human NCI-H522 cells after 48 hrs by MTT assay
[PMID: 29370702]
OVCAR-3 GI50
8 μM
Compound: 11d
Growth inhibition of human OVCAR3 cells after 48 hrs by MTT assay
Growth inhibition of human OVCAR3 cells after 48 hrs by MTT assay
[PMID: 29370702]
OVCAR-4 GI50
9 μM
Compound: 11d
Growth inhibition of human OVCAR4 cells after 48 hrs by MTT assay
Growth inhibition of human OVCAR4 cells after 48 hrs by MTT assay
[PMID: 29370702]
OVCAR-5 GI50
7 μM
Compound: 11d
Growth inhibition of human OVCAR5 cells after 48 hrs by MTT assay
Growth inhibition of human OVCAR5 cells after 48 hrs by MTT assay
[PMID: 29370702]
PANC-1 GI50
4 μM
Compound: 11d
Growth inhibition of human PANC1 cells after 48 hrs by MTT assay
Growth inhibition of human PANC1 cells after 48 hrs by MTT assay
[PMID: 29370702]
PC-3 GI50
3 μM
Compound: 11d
Growth inhibition of human PC3 cells after 48 hrs by MTT assay
Growth inhibition of human PC3 cells after 48 hrs by MTT assay
[PMID: 29370702]
T47D GI50
6 μM
Compound: 11d
Growth inhibition of human T47D cells after 48 hrs by MTT assay
Growth inhibition of human T47D cells after 48 hrs by MTT assay
[PMID: 29370702]
分子量

462.32

Formula

C23H21Cl2NO5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IIIM-290 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IIIM-2902213468-64-3IIIM290IIIM 290CDKCyclin dependent kinaseInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-111356
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