1. Anti-infection
  2. Fungal Bacterial Antibiotic
  3. Kanosamine hydrochloride

Kanosamine hydrochloride是一种抗生素,可抑制植物病原卵菌,某些真菌 (fungi) 和细菌 (bacterial) 的生长。Kanosamine抑制 Phytophthora medicaginis M2913 和 Aphanomyces euteiches WI-98的MIC 分别为25 和 60 µg/mL。

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Kanosamine hydrochloride Chemical Structure

Kanosamine hydrochloride Chemical Structure

CAS No. : 57649-10-2

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  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Kanosamine hydrochloride is an antibiotic which inhibits the growth of plant-pathogenic oomycetes, certain fungi and a few bacterial species. Kanosamine inhibits Phytophthora medicaginis M2913 and Aphanomyces euteiches WI-98 with MICs of 25 and 60 µg/mL, respectively.

IC50 & Target

MIC: 25 µg/mL (Phytophthora medicaginis M2913), 60 µg/mL (Aphanomyces euteiches WI-98)[1]

体外研究
(In Vitro)

Kanosamine is highly inhibitory to growth of plant-pathogenic oomycetes. Among the strains tested, Phytophthora medicaginis M2913 is the most sensitive to kanosamine, whereas Pythium aphanidermatum Pa138 and Pythium torulosum A25a are less sensitive, and Aphanomyces euteiches WI-98 shows an intermediate level of sensitivity. The oomycetes are more sensitive to kanosamine at pH 7.0 than at pH 5.6. Kanosamine inhibits few bacterial species. Kanosamine is moderately inhibitory to certain fungi. All of the fungi and oomycetes inhibited by kanosamine are pathogens of plants. Maximum accumulation of kanosamine in B. cereus UW85 culture supernatants coincided with sporulation. Kanosamine accumulation is enhanced by the addition of ferric iron and suppressed by addition of phosphate to rich medium. Kanosamine accumulation is also enhanced more than 300% by the addition of alfalfa seedling exudate to minimal medium[1]. The antibiotic kanosamine inhibits growth of Saccharomyces cerevisiae and a range of human pathogenic fungi, including Candida albicans. The action of kanosamine on C. albicans cells results in profound morphological changes, inhibition of septum formation and cell agglutination[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

215.63

Formula

C6H14ClNO5

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料

纯度: ≥98.0%

参考文献
Cell Assay
[1]

MICs are determined by a serial dilution microtitrer plates method in Yeast Nitrogen Base medium containing 1% glucose or glycerol as a carbon source. Wells containing serially diluted kanosamine and control wells are inoculated with 105 cells /mL of an overnight culture of fungal cells and incubated for 24 h at 30°C. MIC is defined as the lowest antifungal agent concentration preventing visible growth. Alternatively, MICs are determined in RPMI 1640 medium buffered with 3-[N-morpholino]propanesulphonic acid (MOPS) to pH 7, under conditions recommended by NCCLS. In all cases, reproducible sharp end points are obtained and trailing effects are not observed[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

Kanosamine hydrochloride 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Kanosamine hydrochloride
目录号:
HY-112176
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