2. Immunology/Inflammation
  3. COX
  4. Nitroflurbiprofen

Nitroflurbiprofen  (Synonyms: 硝基氟比洛芬; HCT 1206; NO-flurbiprofen; Nitroxybutyl flurbiprofen)

目录号: HY-U00013 纯度: 99.58%
COA 产品使用指南

摩尔计算器

Nitroflurbiprofen 是一种环氧合酶 (COX) 抑制剂。

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Nitroflurbiprofen Chemical Structure

Nitroflurbiprofen Chemical Structure

CAS No. : 158836-71-6

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5 mg ￥3800
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Nitroflurbiprofen 相关抗体

Top Publications Citing Use of Products

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COX COX-1 COX-2 COX-3

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nitroflurbiprofen is a cyclooxygenase (COX) inhibitor with nitric oxide (NO)-donating properties, modulates the increased intrahepatic vascular tone in portal hypertensive cirrhotic rats.

IC50 & Target[1]

COX

 

体内研究
(In Vivo)

In vivo hemodynamic measurements (n = 8/condition) and evaluation of the increased intrahepatic resistance by in situ perfusion (n=5/condition) are performed in rats with thioacetamide-induced cirrhosis that receive either Nitroflurbiprofen (45 mg/kg), Flurbiprofen (30 mg/kg, equimolar concentration to Nitroflurbiprofen), or vehicle by intraperitoneal injection 24 hours and 1 hour prior to the measurements. Treatment with Nitroflurbiprofen, an NO-releasing cyclooxygenase inhibitor, improves portal hypertension without major adverse effects in thioacetamide-induced cirrhotic rats by attenuating intrahepatic vascular resistance, endothelial dysfunction, and hepatic hyperreactivity to vasoconstrictors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

361.36

Formula

C19H20FNO5
CAS 号
性状

油状物

颜色

Colorless to light yellow

中文名称

硝基氟比洛芬
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 99.64%

COA (166 KB) HNMR (224 KB) LCMS (530 KB)

产品使用指南 (1538 KB)
参考文献
Animal Administration
[1]

Rats[1]
Male Wistar rats, weighing 200-250 g, are used. After 18 weeks of TAA administration, cirrhotic rats are equally (n=8/group) and randomly allocated to one of the following groups: intraperitoneal injection, 24 hours and 1 hour prior to the measurements, with Nitroflurbiprofen (45 mg/kg), Flurbiprofen (30 mg/kg, equimolar concentration to Nitroflurbiprofen), or vehicle (250 μL DMSO:250 μL isotonic saline). The used dose is based on a dose-finding study (n=5 per condition). The concentrations of Nitroflurbiprofen (15 mg/kg) and Flurbiprofen (7.5 mg/kg, equimolar concentration to Nitroflurbiprofen Flurbiprofen) are started, then are increased the dose to Nitroflurbiprofen 22.5 mg/kg and Flurbiprofen 15 mg/kg, and, finally, Nitroflurbiprofen 45 mg/kg and Flurbiprofen 30 mg/kg. The last dose regimen has the most profound hemodynamic effects.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Nitroflurbiprofen 相关分类

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Keywords:

Nitroflurbiprofen158836-71-6HCT 1206 NO-flurbiprofen Nitroxybutyl flurbiprofen硝基氟比洛芬HCT1206HCT-1206COXCyclooxygenaseInhibitorinhibitorinhibit

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