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  3. Orphenadrine hydrochloride

Orphenadrine hydrochloride  (Synonyms: 盐酸奥芬那君;盐酸邻甲苯海拉明;奥芬那君盐酸盐)

目录号: HY-B1126
产品使用指南

Orphenadrine hydrochloride 是一种口服有效的非竞争性 NMDA 受体拮抗剂 (可透过血脑屏障),其 Ki 值为 6.0 μM。Orphenadrine hydrochloride 能缓解因肌肉拉伤、扭伤或其他损伤引起的僵硬、疼痛和不适,也用于缓解帕金森病引起的颤抖。Orphenadrine hydrochloride 具有较好的神经保护作用,可用于神经退行性疾病的研究。

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Orphenadrine hydrochloride Chemical Structure

Orphenadrine hydrochloride Chemical Structure

CAS No. : 341-69-5

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Orphenadrine hydrochloride 的其他形式现货产品:

Other Forms of Orphenadrine hydrochloride:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Orphenadrine hydrochloride is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a Ki of 6.0 μM. Orphenadrine hydrochloride relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine hydrochloride is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases[1][2].

体外研究
(In Vitro)

Orphenadrine hydrochloride (12 µM; 24.5 h) shows neuroprotective effects on 3-NPA-induced neurotoxicity cerebellar granule cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: CGC cells (7-day-old Sprague Dawley rat)
Concentration: 6, 12, 24, 48 µM
Incubation Time: 24.5 h
Result: Prevented cells from 3-NPA induced cellular aggregation,volume diminution and neurite fragmentation.
体内研究
(In Vivo)

Orphenadrine hydrochloride (10, 20, 30 mg/kg; i.p.; once aday for 3 days) reduces 3-NPA-induced mortality in a dose-dependent manner[1].
Orphenadrine hydrochloride (30 mg/kg; i.p.; once aday for 3 days) shows activity to against 3-NPA-induced neuronal damage in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague Dawley rats (275-300 g; 3-NPA toxicity model)[1].
Dosage: 10, 20, 30 mg/kg
Administration: Intraperitoneal injection; once aday for 3 days (30 min before 3-NPA)
Result: Reduced mortality of 3-NPA toxicity rats to 10-40% (3-NPA-treated animals showed general incoordination, drowsiness and general weakness).
Recovered 3-NPA-induced body weight loss, and when at 30 mg/kg reduced the level of PBR and expression of HSP27. (PBR and HSP27 are markers of neuronal damage).
Clinical Trial
分子量

305.84

Formula

C18H24ClNO

CAS 号
中文名称

盐酸奥芬那君;盐酸邻甲苯海拉明;奥芬那君盐酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Orphenadrine hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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