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  3. Rispenzepine

Rispenzepine  (Synonyms: 利喷西平)

目录号: HY-U00030
产品使用指南

Rispenzepine 是一种选择性毒蕈碱受体 (M1M3 受体亚型) 拮抗剂。

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Rispenzepine Chemical Structure

Rispenzepine Chemical Structure

CAS No. : 96449-05-7

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Rispenzepine is a novel antimuscarinic compound with a preferential action at M1, and M3 receptor subtypes.

IC50 & Target

M1, and M3 receptor[1]

体外研究
(In Vitro)

The presence of muscarinic autoreceptors in human and guinea pig trachea is investigated by comparing the effects of the muscarinic receptor antagonists Pirenzepine (M1), Methoctramine (M2), 4-DAMP (M3), and Rispenzepine (M1/M3) on cholinergic neural contractile responses evoked by electrical field stimulation (EFS) and [3H]ACh release. The M1, M1/M3, or M3 antagonists inhibit the EFS-evoked cholinergic contractile response in a concentration-dependent manner (4-DAMP > Rispenzepine > Pirenzepine), whereas Methoctramine facilitates this response at low concentrations (<3 μM). In ACh release studies, the M3 antagonist has no significant effect, whereas Pirenzepine, Methoctramine, and Rispenzepine significantly increase ACh release in guinea pig trachea. Rispenzepine almost completely inhibits cholinergic, contractile responses at 0.3 μM (92.7±6.2% inhibition, n=6, p<0.05; pD2 value of 7.31±0.15) [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

336.39

Formula

C19H20N4O2

CAS 号
中文名称

利喷西平

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Rispenzepine 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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HY-U00030
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