2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. Talarozole (R enantiomer)

Talarozole (R enantiomer)  (Synonyms: (R)-Talarozole)

目录号: HY-14802
产品使用指南

摩尔计算器

Talarozole R enantiomer是一个强的，有选择性的细胞色素P450，CYP26的抑制剂。

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Talarozole (R enantiomer) Chemical Structure

Talarozole (R enantiomer) Chemical Structure

CAS No. : 870093-23-5

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规格 价格 是否有货
5 mg ￥3438
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Customer Review

Other Forms of Talarozole (R enantiomer):

Talarozole (R enantiomer) 相关抗体

Top Publications Citing Use of Products

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Talarozole R enantiomer is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid for the treatment of psoriasis and acne. Target: CYP26 in vitro: Talarozole R enantiomer treatment increased the mRNA expression of CRABP2, KRT4, CYP26A1 and CYP26B1 dose dependently, and decreased theexpression of KRT2 and IL-1alpha compared with vehicle-treated skin. No mRNA change in retinol-metabolizing enzymes was obtained. There was no induction of epidermal thickness or overt skin inflammation in talarozole-treated skin. Immunofluorescence analysis confirmed an upregulation of KRT4 protein, but no upregulation of CYP26A1 and CYP26B1 expression was detected [1] [2]. in vivo: Talarozole R enantiomer slightly diffused into the skin only when dissolved in propylene glycol, isopropyl myristate or ethanol. Although only 0.1% of the dose applied was found in the skin itself after 12-24 h, this was sufficient to achieve local concentrations well above the half-maximal inhibitory concentration value for talarozole. The distribution of talarozole within the skin was investigated: 80% was located in the epidermis, while the remaining 20% was found in the dermis [3].

分子量

377.51

Formula

C21H23N5S
CAS 号
中文名称

(R)-他拉罗唑
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据
In Vitro: 

DMSO 中的溶解度 : ≥ 51 mg/mL (135.10 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.6489 mL 13.2447 mL 26.4894 mL
5 mM 0.5298 mL 2.6489 mL 5.2979 mL
查看完整储备液配制表

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Talarozole (R enantiomer) 相关分类

完整储备液配制表

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6489 mL 13.2447 mL 26.4894 mL 66.2234 mL
5 mM 0.5298 mL 2.6489 mL 5.2979 mL 13.2447 mL
10 mM 0.2649 mL 1.3245 mL 2.6489 mL 6.6223 mL
15 mM 0.1766 mL 0.8830 mL 1.7660 mL 4.4149 mL
20 mM 0.1324 mL 0.6622 mL 1.3245 mL 3.3112 mL
25 mM 0.1060 mL 0.5298 mL 1.0596 mL 2.6489 mL
30 mM 0.0883 mL 0.4415 mL 0.8830 mL 2.2074 mL
40 mM 0.0662 mL 0.3311 mL 0.6622 mL 1.6556 mL
50 mM 0.0530 mL 0.2649 mL 0.5298 mL 1.3245 mL
60 mM 0.0441 mL 0.2207 mL 0.4415 mL 1.1037 mL
80 mM 0.0331 mL 0.1656 mL 0.3311 mL 0.8278 mL
100 mM 0.0265 mL 0.1324 mL 0.2649 mL 0.6622 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Talarozole (R enantiomer)870093-23-5(R)-Talarozole(R)-他拉罗唑Cytochrome P450CYPsInhibitorinhibitorinhibit

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