2. Cell Cycle/DNA Damage
  3. G-quadruplex
  4. SOP1812

SOP1812  (Synonyms: QN-302)

目录号: HY-148012 纯度: 98.46%
COA 产品使用指南 技术支持

SOP1812 (QN-302) 是一种 naphthalene diimide (ND) 衍生物，具有抗肿瘤活性。SOP1812 能够与quadruplex arrangements (G4s) 结合，并下调多个癌症基因通路。SOP1812 对 hTERT G4 和 HuTel21 具有很强的亲和力，其 KD 值分别为 4.9 和 28.4 nM。G4SOP1812 可用于癌症的研究。

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SOP1812

SOP1812 Chemical Structure

CAS No. : 2546091-70-5

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1 mg ￥500
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5 mg ￥990
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10 mg ￥1485
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25 mg ￥2970
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50 mg ￥4455
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SOP1812 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SOP1812 (QN-302) is a naphthalene diimide (ND) derivative with anti-tumor activity. SOP1812 binds to quadruplex arrangements (G4s), and down-regulates several cancer gene pathways. SOP1812 shows great affinity to hTERT G4 and HuTel21 G4 with KD values of 4.9 and 28.4 nM, respectively. SOP1812 can be used for the research of cancer[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BXPC-3 GI50
2.6 nM
Compound: 11; SOP1812
Antiproliferative activity against human BxPC3 cells assessed as growth inhibition after 96 hrs by SRB assay
Antiproliferative activity against human BxPC3 cells assessed as growth inhibition after 96 hrs by SRB assay
[PMID: 32832034]
CAPAN-1 GI50
5.9 nM
Compound: 11; SOP1812
Antiproliferative activity against human Capan1 cells assessed as growth inhibition after 96 hrs by SRB assay
Antiproliferative activity against human Capan1 cells assessed as growth inhibition after 96 hrs by SRB assay
[PMID: 32832034]
MIA PaCa-2 GI50
1.3 nM
Compound: 11; SOP1812
Antiproliferative activity against human MIAPaCa2 cells assessed as growth inhibition after 96 hrs by SRB assay
Antiproliferative activity against human MIAPaCa2 cells assessed as growth inhibition after 96 hrs by SRB assay
[PMID: 32832034]
PANC-1 GI50
1.4 nM
Compound: 11; SOP1812
Antiproliferative activity against human PANC1 cells assessed as growth inhibition after 96 hrs by SRB assay
Antiproliferative activity against human PANC1 cells assessed as growth inhibition after 96 hrs by SRB assay
[PMID: 32832034]
体外研究
(In Vitro)

SOP1812 (0-50 nM；96 小时) 抑制多种癌细胞的增殖[1]。
SOP1812 (0-800 nM；6-24 小时) 对 hTERT G4 和 HuTel21 G4 具有很强的亲和力[1]。
SOP1812 (40 nM；6-24 小时) 影响 Wnt/β-连环蛋白、轴突导向、Hippo、MAPK 和 Rap1 通路[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SOP1812 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MIA PaCa-2, PANC-1, Capan-1 and BxPC-3 cell lines
Concentration: 0-50 nM
Incubation Time: 96 hours
Result: Showed anti-proliferation ability to MIA PaCa-2, PANC-1, Capan-1 and BxPC-3 cells with GI50 values of 1.3, 1.4, 5.9 and 2.6 nM, respectively.

Cell Viability Assay[1]

Cell Line: PANC-1 cells
Concentration: 0, 100, 400 and 800 nM
Incubation Time: 6 and 24 hours
Result: Binded to hTERT G4 and HuTel21 G4 with KD values of 4.9 and 28.4 nM, respectively.

Cell Viability Assay[1]

Cell Line: MIA PaCa-2 Cells
Concentration: 40 nM
Incubation Time: 6 and 24 hours
Result: Affected WNT5B, DVL1, AXIN and APC2 expression which includes in Wnt/β-catenin pathway and also showed effects on axon guidance, Hippo, MAPK, and Rap1 pathways.
体内研究
(In Vivo)

SOP1812 (1 mg/kg；每周静脉注射一次或两次，持续 28 天) 在 MIA PaCa-2 异种移植小鼠和 KPC 小鼠[1]中显示出抗肿瘤活性。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female athymic nude mice with MIA PaCa-2 xenografts[1]
Dosage: 1 mg/kg
Administration: Intravenous injection; 1 mg/kg once or twice per week; for 28 days
Result: Showed complete tumor regression and no significant tumor regrowth after day 28 on several animals.
Animal Model: KPC mice with PDAC symptoms[1]
Dosage: 1 mg/kg
Administration: Intravenous injection; 1 mg/kg once per week; for 3 weeks
Result: Significantly extended survival of KPC mice and showed a better effect than gemcitabine.
Clinical Trial
分子量

791.98

Formula

C45H57N7O6
CAS 号
性状

固体

颜色

Brown to reddish brown

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

SOP1812 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SOP18122546091-70-5QN-302SOP 1812SOP-1812QN302QN 302G-quadruplexNDquadruplexMIA PaCa-2G4Wnt/β-cateninPANC-1BxPC-3PDACInhibitorinhibitorinhibit

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