2. Cell Cycle/DNA Damage Apoptosis GPCR/G Protein MAPK/ERK Pathway
  3. G-quadruplex Bcl-2 Family Ras Caspase
  4. MM41

MM41 是一种四链体 (quadruplex) 相互作用化合物。MM41 与 BCL-2 和 k-RAS 基因启动子序列中编码的四链体紧密结合。MM41 减少 BCL-2 和 k-RAS 蛋白水平、增加 caspase 3。MM41 对胰腺癌具有抗肿瘤作用。

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MM41

MM41 Chemical Structure

CAS No. : 1429028-96-5

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规格 价格 是否有货 数量
1 mg ￥590
In-stock
5 mg ￥1488
In-stock
10 mg ￥2363
In-stock
25 mg ￥3863
In-stock
50 mg ￥5188
In-stock
100 mg 现货 询价
200 mg   询价  
500 mg   询价  

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Customer Review

MM41 相关抗体

Top Publications Citing Use of Products

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3

查看 Ras 亚型特异性产品:

查看所有亚型
K-Ras H-Ras N-Ras Ras

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MM41 is a quadruplex-interacting compound. MM41 binds tightly to quadruplexes encoded in the promoter sequences of the BCL-2 and k-RAS genes. MM41 reduces BCL-2 and k-RAS protein levels, increases caspase 3. MM41 has antitumor effects against pancreatic cancer[1].

IC50 & Target[1]

Caspase 3

 

Bcl-2

 

K-RAS

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
786-0 IC50
0.32 μM
Compound: 3d
Cytotoxicity against human 786-0 cells assessed as growth inhibition after 96 hrs by SRB assay
Cytotoxicity against human 786-0 cells assessed as growth inhibition after 96 hrs by SRB assay
[PMID: 23514618]
A549 IC50
< 0.01 μM
Compound: 3d
Cytotoxicity against human A549 cells assessed as growth inhibition after 96 hrs by SRB assay
Cytotoxicity against human A549 cells assessed as growth inhibition after 96 hrs by SRB assay
[PMID: 23514618]
A549 IC50
19 nM
Compound: MM41
Growth inhibition of human A549 cells after 96 hrs by SRB assay
Growth inhibition of human A549 cells after 96 hrs by SRB assay
[PMID: 29356532]
MCF7 IC50
0.07 μM
Compound: 3d
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 96 hrs by SRB assay
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 96 hrs by SRB assay
[PMID: 23514618]
MCF7 IC50
70 nM
Compound: MM41
Growth inhibition of human MCF7 cells after 96 hrs by SRB assay
Growth inhibition of human MCF7 cells after 96 hrs by SRB assay
[PMID: 29356532]
MIA PaCa-2 IC50
0.01 μM
Compound: 3d
Cytotoxicity against human MIAPaCa2 cells assessed as growth inhibition after 96 hrs by SRB assay
Cytotoxicity against human MIAPaCa2 cells assessed as growth inhibition after 96 hrs by SRB assay
[PMID: 23514618]
MIA PaCa-2 IC50
11 nM
Compound: MM41
Growth inhibition of human MIAPaCa2 cells after 96 hrs by SRB assay
Growth inhibition of human MIAPaCa2 cells after 96 hrs by SRB assay
[PMID: 29356532]
PANC-1 IC50
0.003 μM
Compound: 2a
Cytotoxicity against human PANC1 cells after 96 hrs by SRB assay
Cytotoxicity against human PANC1 cells after 96 hrs by SRB assay
[PMID: 23769166]
PANC-1 IC50
3 nM
Compound: MM41
Growth inhibition of human PANC1 cells after 96 hrs by SRB assay
Growth inhibition of human PANC1 cells after 96 hrs by SRB assay
[PMID: 29356532]
RCC4 IC50
0.56 μM
Compound: 3d
Cytotoxicity against human RCC4 cells assessed as growth inhibition after 96 hrs by SRB assay
Cytotoxicity against human RCC4 cells assessed as growth inhibition after 96 hrs by SRB assay
[PMID: 23514618]
WI-38 IC50
0.23 μM
Compound: 3d
Cytotoxicity against human WI38 cells assessed as growth inhibition after 96 hrs by SRB assay
Cytotoxicity against human WI38 cells assessed as growth inhibition after 96 hrs by SRB assay
[PMID: 23514618]
WI-38 IC50
230 nM
Compound: MM41
Growth inhibition of human WI38 cells after 96 hrs by SRB assay
Growth inhibition of human WI38 cells after 96 hrs by SRB assay
[PMID: 29356532]
体外研究
(In Vitro)

MM41 (1 μM) 可稳定 BCL-2 启动子 G-四链体，ΔTₘ 值为 26.4 °C，并且可有效结合 k-RAS1 和 k-RAS2 启动子 G-四链体，ΔTₘ 值分别为 22.5 °C 和 19.8 °C[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MM41 相关抗体:
体内研究
(In Vivo)

MM41 (10-15 mg/kg；静脉注射；每周两次；12 次) 在 MIA PaCa-2 胰腺癌异种移植瘤中表现出剂量依赖性抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female CD-1 nude mice (2-3 months old, weighing 20-25 g) bearing MIA PaCa-2 pancreatic cancer subcutaneous xenografts[1]
Dosage: 10 mg/kg, 15 mg/kg
Administration: Intravenous administration, twice weekly, 12 doses
Result: Resulted in an average reduction of ca 80% in tumor growth by day 40 in mice, cessation of tumor regrowth from day 30 onwards, and complete tumor regression in two mice with no regrowth for 239 days (15 mg/kg).
Showed weaker anti-tumour effect (10 mg/kg).
Showed reduced BCL-2 and k-RAS protein levels in treated tumours.
Showed that treated tumours, but not untreated ones, show high levels of caspase 3 staining.
分子量

831.06

Formula

C44H66N10O6
CAS 号
性状

固体

颜色

Blue to purple

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 33.33 mg/mL (40.11 mM; ultrasonic and adjust pH to 8 with HCl; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.2033 mL 6.0164 mL 12.0328 mL
5 mM 0.2407 mL 1.2033 mL 2.4066 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

MM41 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2033 mL 6.0164 mL 12.0328 mL 30.0821 mL
5 mM 0.2407 mL 1.2033 mL 2.4066 mL 6.0164 mL
10 mM 0.1203 mL 0.6016 mL 1.2033 mL 3.0082 mL
15 mM 0.0802 mL 0.4011 mL 0.8022 mL 2.0055 mL
20 mM 0.0602 mL 0.3008 mL 0.6016 mL 1.5041 mL
25 mM 0.0481 mL 0.2407 mL 0.4813 mL 1.2033 mL
30 mM 0.0401 mL 0.2005 mL 0.4011 mL 1.0027 mL
40 mM 0.0301 mL 0.1504 mL 0.3008 mL 0.7521 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MM411429028-96-5MM 41MM-41G-quadruplexBcl-2 FamilyRasCaspasePaCa-2pancreatic cancerA549RCC4,786-0cancer,stabilizerInhibitorinhibitorinhibit

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