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MSAB 

目录号: HY-120697
产品使用指南

MSAB 是 Wnt/β-catenin 信号传导的有效和选择性抑制剂。MSAB 与 β-catenin 结合,促进其降解,并特别下调 Wnt/β-catenin 靶基因。MSAB 对 Wnt 依赖性癌细胞显示出有效的抗肿瘤作用。

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MSAB Chemical Structure

MSAB Chemical Structure

CAS No. : 173436-66-3

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Description

MSAB is a potent and selective inhibitor of Wnt/β-catenin signaling. MSAB binds to β-catenin promoting its degradation, and specifically downregulates Wnt/β-catenin target genes. MSAB exhibits potent anti-tumor effects selectively on Wnt-dependent cancer cells[1].

IC50 & Target

Wnt/β-catenin[1]

In Vitro

MSAB (2-10 μM) selectively decreases cell viability of Wnt-dependent cells while showing little effect on Wnt-independent cells and normal human cells[1].
MSAB (0.01-10 μM; 20 h) inhibits T-cell factor (TCF) luciferase reporter activity in HCT116 cells[1].
MSAB (20 h) suppresses the Wnt3a-induced TOP-Luc activation and increases of active β-catenin levels in HEK293T cells[1].
MSAB (0.5-10 μM; 20 h) decreases mRNA and protein levels of endogenous Wnt target genes in HCT116 cells[1].
MSAB (5 μM; 16 h) induces degradation of β-catenin in a proteasome-dependent manner in HCT116 cells[1].

In Vivo

MSAB (10-20 mg/kg; i.p. daily for 2 weeks) inhibits tumor growth of Wnt-dependent cancer cells in mouse xenograft model[1].
MSAB (10-20 mg/kg; i.p. twice daily for 2 weeks) inhibits tumor growth of MMTV-Wnt1 transgenic mice[1].

Animal Model: Athymic nude mice (5-6 weeks) are injected HCT116, HT115, H23, or H460 cells[1]
Dosage: 10, 20 mg/kg
Administration: I.p. daily for 2 weeks
Result: Reduced the size and weight of various types of Wnt-dependent HCT116, HT115, and H23 tumors.
Molecular Weight

305.35

Formula

C₁₅H₁₅NO₄S

CAS No.

173436-66-3

SMILES

O=C(C1=CC=CC(NS(=O)(C2=CC=C(C=C2)C)=O)=C1)OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

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× = ×
C1   V1   C2   V2

Keywords:

MSABWntβ-catenindegradationanti-tumorcancerInhibitorinhibitorinhibit

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MSAB
目录号:
HY-120697
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