2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Malate Dehydrogenase (MDH)

Malate Dehydrogenase (MDH) 

Malate Dehydrogenase

Malate Dehydrogenase (MDH) is an enzyme that plays a key role in cellular metabolism and belongs to the NAD-dependent dehydrogenase family. Malate Dehydrogenase (MDH) catalyzes the reversible conversion between malate and oxaloacetate. There are multiple subtypes of MDH. In eukaryotes, there are mainly cytoplasmic MDH1, mitochondrial MDH2, and MDH present in peroxisomes, glyoxysomes, and chloroplasts; there is only one MDH in prokaryotes such as Escherichia coli. MDH1 is closely related to the proliferation and survival of tumor cells, and its high expression is associated with a poor prognosis of non-small cell lung cancer. MDH1 plays an important role in replenishing cytoplasmic NAD to support glycolysis during cell proliferation, and together with lactate dehydrogenase (LDH), maintains the intracellular NAD supply; in cardiovascular disease research, it was found that changes in its activity are related to energy metabolism, oxidative stress and other processes in cardiac tissue. In addition, MDH participates in important metabolic pathways such as the tricarboxylic acid cycle, gluconeogenesis, and amino acid synthesis, and plays a role in different cellular compartments. For example, MDH transports reducing equivalents between the cytoplasm and mitochondria through the malate-aspartate shuttle, maintaining cellular energy metabolism and normal physiological functions[1][2][3][4][5][6].

Malate Dehydrogenase (MDH) 相关产品 (6):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-147791
    MDH1-IN-2 Inhibitor 98.70%
    MDH1-IN-2 (Compound 7c) 是一种选择性 MDH1 抑制剂，对 MDH1 和 MDH2 的 IC50 分别为 2.27 和 27.47 μM。MDH1-IN-2 可通过抑制 MDH1 介导的 2-Ketoglutaric acid (HY-W013636) 向 α-Hydroxyglutaric acid (HY-113038B) 转化，减少 ROS 生成，进而抑制 2-Ketoglutaric acid (HY-W013636) 诱导的铁死亡 (ferroptosis)。
    MDH1-IN-2
  • HY-W613220
    MDH1/2-IN-1 Inhibitor 99.53%
    MDH1/2-IN-1 是一种 MDH1/2 抑制剂 (IC50 分别为 1.07 nM 和 1.06 nM)。 MDH1/2-IN-1 可抑制线粒体呼吸和 HIF-1α 通路。MDH1/2-IN-1 显示出显著的抗肿瘤潜力。MDH1/2-IN-1 为开发靶向癌症代谢的药物提供了新的方向。
    MDH1/2-IN-1
  • HY-P3001B
    Malate Dehydrogenase, Porcine
    Malate Dehydrogenase, Porcine 是一种催化苹果酸转化为草酰乙酸的脱氢酶。
    Malate Dehydrogenase, Porcine
  • HY-P2809B
    Malic Dehydrogenase, Porcine
    Malic Dehydrogenase, Porcine (EC 1.1.1.37) 在真核细胞中以两种同工酶的形式存在，一种在细胞线粒体中表达，并在三羧酸循环中发挥作用；另一种在细胞质中表达，将线粒体中的苹果酸转化回草酰乙酸。
    Malic Dehydrogenase, Porcine
  • HY-P2809A
    Malic Dehydrogenase, Thermus flavus
    Malic Dehydrogenase, Thermus flavus (EC 1.1.1.37) 在真核细胞中以两种同工酶的形式存在，一种在细胞线粒体中表达，并在三羧酸循环中发挥作用；另一种在细胞质中表达，将线粒体中的苹果酸转化回草酰乙酸。
    Malic Dehydrogenase, Thermus flavus
  • HY-P3001A
    Malate Dehydrogenase,Yeast
    Malate Dehydrogenase,Yeast (EC 1.1.1.37) 是柠檬酸循环中的一种酶，它催化苹果酸转化为草酰乙酸 (需要 NAD+)。Malate Dehydrogenase 参与糖异生，即由小分子合成葡萄糖的过程。
    Malate Dehydrogenase,Yeast
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