Glycine Receptor (GlyR) 

Glycine Receptor (GlyR) is a ligand-gated chloride ion channel. GlyR can specifically bind to the neurotransmitter glycine, mediate the influx of chloride ions, thereby generating inhibitory postsynaptic potentials and regulating the excitability of neurons. GlyR can be activated by a series of simple amino acids, such as glycine, alanine, and taurine. GlyR is involved in various physiological functions such as sensory information processing, motor control, pain perception, and cognition, and plays a crucial role in the process of neural signal transmission. Abnormal functions of GlyR are associated with multiple neurodevelopment-related disorders, such as autism and epilepsy^[1].

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