Prokineticin Receptor (前动力蛋白受体)

Prokineticin Receptors (PKRs) are a class of G protein-coupled receptors comprising two subtypes, PKR1 and PKR2. They bind to endogenous ligands prokineticin (PK1 and PK2) and play pivotal roles in regulating various important physiological and pathological processes. Research has demonstrated that PKRs are critically involved in angiogenesis, neurogenesis, pain perception, reproductive functions, and circadian rhythm regulation^[1].
PKR1 is primarily expressed in the cardiovascular system and peripheral tissues, where it participates in angiogenesis and cardioprotection, while PKR2 is predominantly distributed in the central nervous system, modulating neuronal development and synaptic plasticity . Upon activation, PKRs mainly signal through the Gq/11 protein-coupled pathway, stimulating phospholipase C (PLC) activation, which subsequently induces intracellular calcium release and protein kinase C (PKC) activation^[2].