2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Prolyl Endopeptidase (PREP)

Prolyl Endopeptidase (PREP) (脯氨酸内肽酶)

prolyl oligopeptidase; POP

Prolyl endopeptidase (PREP), also known as prolyl oligopeptidase (POP), a member of the serine protease family, which can specifically hydrolyze the peptide bond of the carboxylterminus of the proline residue in the polypeptide chain, has high activity in the liver. Accumulated evidence suggests that PREP participates in physiological and pathological processes, including maturation and degradation of peptides, inflammation, oxidative stress, autophagy, cell proliferation and cancer.

Prolyl Endopeptidase (PREP) 相关产品 (25):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-143474
    POP-IN-3 Inhibitor
    Y-29794 (Compound 2) 是一种有效的、共价结合的 prolyl oligopeptidase (POP) 抑制剂，Ki 值为 0.95 nM。Y-29794 可用于研究神经退行性疾病和癌症。
    POP-IN-3
  • HY-148331
    Z-Thioprolyl-Thioproline Inhibitor
    Z-Thioprolyl-Thioproline 是一种牛脑的脯氨酰内肽酶 (PEP) 抑制剂 (IC50=16 µM; Ki=37 µM)。Z-Thioprolyl-Thioproline 可用于神经性疾病 (如记忆障碍和认知障碍) 的研究。
    Z-Thioprolyl-Thioproline
  • HY-143475
    POP-IN-2 Inhibitor
    POP-IN-2 (Compound 7k) 是一种有效的、共价结合的 prolyl oligopeptidase (POP) 抑制剂，Ki 值为 6 nM。POP-IN-2 可用于研究神经退行性疾病和癌症。
    POP-IN-2
  • HY-134454A
    Z-Pro-prolinal Inhibitor
    Z-Pro-prolinal (N-Benzyloxycarbonyl-L-prolyl-L-prolinal) 是一种特异的，具有口服活性的脯氨酰寡肽酶 (PREP) 抑制剂，对于猪 PREP 的 IC50 为 0.4 nM。
    Z-Pro-prolinal
  • HY-P4490
    Suc-Ala-Pro-pNA
    Suc-Ala-Pro-pNA 是一种肽，可作为底物检测脯氨酰内肽酶 (PEP) 的活性和稳定性。
    Suc-Ala-Pro-pNA
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