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  3. YM-53601 free base

YM-53601 free base 

目录号: HY-100313
产品使用指南

YM-53601 free base是角鲨烯合成酶抑制剂,其抑制啮齿类动物的脂肪生物合成和脂质分泌。

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YM-53601 free base Chemical Structure

YM-53601 free base Chemical Structure

CAS No. : 182959-28-0

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  • 生物活性

  • 实验参考方法

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  • 参考文献

生物活性

YM-53601 free base is a squalene synthetase inhibitor which suppresses lipogenic biosynthesis and lipid secretion in rodents.

IC50 & Target

Target: Squalene synthetase[1]

体内研究
(In Vivo)

YM-53601 inhibits cholesterol biosynthesis from acetate in a dose-dependent manner in the plasma of rats. At the same time, YM-53601 inhibits both FFA and triglyceride biosynthesis in rats treated with cholestyramine over the same dose range at which it inhibits cholesterol biosynthesis. YM-53601 by single oral administration decreases the enhanced plasma triglyceride levels in hamsters induced by an injection of protamine sulfate, which inhibits lipoprotein lipase (LPL) and consequently increases plasma very low-density lipoprotein (VLDL) triglyceride levels. YM-53601 also decreases the enhanced plasma triglyceride and cholesterol levels in hamsters treated with Triton WR1339, which also inhibits the degradation of VLDL. Plasma cholesterol was significantly decreased as soon as 1 h after single administration of YM-53601 in hamsters fed a normal diet[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

336.40

Formula

C₂₁H₂₁FN₂O

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
Animal Administration
[1]

Rats[1]

Rats are given a single oral administration of YM-53601 at the concentration of 50 mg/kg, followed 1 h later by intraperitoneal injection of [14C] acetate (40.5 μCi per animal). The rats and the hamsters are anaesthetized with diethyl ether and killed 1 h after the [14C]-acetate injection. Cholesterol biosynthesis is assayed[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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YM-53601 free base
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HY-100313
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