2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor Apoptosis
  3. RAR/RXR Apoptosis
  4. AGN194204

AGN194204  (Synonyms: IRX4204; NRX194204; VTP 194204)

目录号: HY-13717
COA 产品使用指南

摩尔计算器

AGN194204 (IRX4204) 是一种具有口服活性的，选择性 RXR 激动剂，对 RXRα，RXRβ 和 RXRγ 的 Kd 值分别为 0.4 nM，3.6 nM 和 3.8 nM，EC50 分别为 0.2 nM，0.8 nM 和 0.08 nM。AGN194204 对 RAR 无活性，并具有抗炎和抗癌作用。

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AGN194204 Chemical Structure

AGN194204 Chemical Structure

CAS No. : 220619-73-8

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规格 价格 是否有货 数量
1 mg ￥5000
In-stock
5 mg ￥9500
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50 mg   询价  

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Customer Review

AGN194204 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AGN194204 (IRX4204) is an orally active and selective RXR agonist with Kd values 0.4 nM, 3.6 nM and 3.8 nM and EC50s of 0.2 nM, 0.8 nM and 0.08 nM for RXRα, RXRβ and RXRγ, respectively. AGN194204 is inactive against RAR. AGN194204 has anti-inflammatory and anticarcinogenic actions[1][2].

体外研究
(In Vitro)

AGN194204 (NRX194204; 0-100 nM; 24 hours; E, RAW cells) treatment blocks the ability of lipopolysaccharide and tumor necrosis factor-α to induce the release of nitric oxide and interleukin 6 and the degradation of IKBα in RAW264.7 macrophage-like cells[1].
AGN194204 (NRX194204; 1 μM; 72 hours; SK-BR-3 human breast cancer cells) treatment induces apoptosis in breast cancer cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AGN194204 相关抗体:

Apoptosis Analysis[1]

Cell Line: SK-BR-3 human breast cancer cells
Concentration: 1 μM
Incubation Time: 72 hours
Result: Induced apoptosis in lung and breast cancer cells.

Western Blot Analysis[1]

Cell Line: E, RAW cells
Concentration: 0 nM, 1 nM, 10 nM and 100 nM
Incubation Time: 24 hours
Result: Blocked the ability of lipopolysaccharide and tumor necrosis factor-α to induce the release of nitric oxide and interleukin 6 and the degradation of IKBα in RAW264.7 macrophage-like cells.
体内研究
(In Vivo)

AGN194204 (NRX194204; 30-60 mg/kg; oral administration; daily; for 15 weeks; female A/J mice) treatment significantly reduces the number and size of tumors on the surface of the lungs and reduces the total tumor volume per slide by 64% to 81% compared with the control group[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female A/J mice with vinyl carbamate[1]
Dosage: 30 mg/kg, 60 mg/kg
Administration: Oral administration; daily; for 15 weeks
Result: Significantly reduced the number and size of tumors on the surface of the lungs and reduced the total tumor volume per slide by 64% to 81% compared with the control group.
Clinical Trial
分子量

352.51

Formula

C24H32O2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 35 mg/mL (99.29 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8368 mL 14.1840 mL 28.3680 mL
5 mM 0.5674 mL 2.8368 mL 5.6736 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥99.0%

COA (188 KB) 元素分析报告 (205 KB)

产品使用指南 (1538 KB)
参考文献

AGN194204 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8368 mL 14.1840 mL 28.3680 mL 70.9200 mL
5 mM 0.5674 mL 2.8368 mL 5.6736 mL 14.1840 mL
10 mM 0.2837 mL 1.4184 mL 2.8368 mL 7.0920 mL
15 mM 0.1891 mL 0.9456 mL 1.8912 mL 4.7280 mL
20 mM 0.1418 mL 0.7092 mL 1.4184 mL 3.5460 mL
25 mM 0.1135 mL 0.5674 mL 1.1347 mL 2.8368 mL
30 mM 0.0946 mL 0.4728 mL 0.9456 mL 2.3640 mL
40 mM 0.0709 mL 0.3546 mL 0.7092 mL 1.7730 mL
50 mM 0.0567 mL 0.2837 mL 0.5674 mL 1.4184 mL
60 mM 0.0473 mL 0.2364 mL 0.4728 mL 1.1820 mL
80 mM 0.0355 mL 0.1773 mL 0.3546 mL 0.8865 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AGN194204220619-73-8IRX4204 NRX194204 VTP 194204AGN 194204AGN-194204IRX 4204IRX-4204NRX194204NRX 194204NRX-194204VTP194204VTP 194204VTP-194204RAR/RXRApoptosisRetinoic acid receptorsRetinoid X receptorsTNF-αlipopolysaccharideIKBαinterleukin-6anti-inflammatoryanticarcinogenicRXRαRXRβRXRγInhibitorinhibitorinhibit

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目录号：
HY-13717
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