2. Apoptosis
  3. Apoptosis
  4. Alemtuzumab

Alemtuzumab  (Synonyms: 阿伦单抗; Campath-IH)

目录号: HY-P9948 纯度: 97.15%
COA

摩尔计算器

Alemtuzumab (Campath-IH) 是一种针对 CD52 的人源化单克隆抗体，不与鼠 CD52 发生交叉反应。Alemtuzumab 选择性地靶向 CD52 抗原，诱导深度淋巴细胞耗竭，然后恢复具有调节表型的 T 和 B 细胞。Alemtuzumab 能够产生补体依赖性细胞毒性和抗体依赖性细胞介导的细胞毒性 (ADCC)，以及诱导细胞凋亡。Alemtuzumab 具有用于 B 细胞慢性淋巴细胞白血病研究的潜力。

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Alemtuzumab Chemical Structure

Alemtuzumab Chemical Structure

CAS No. : 216503-57-0

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规格 价格 是否有货 数量
1 mg ￥5460
In-stock
5 mg ￥8000
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Alemtuzumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Alemtuzumab (Campath-IH) is a humanized monoclonal antibody against CD52. Alemtuzumab does not cross-react with murine CD52. Alemtuzumab selectively targets the CD52 antigen to induce profound lymphocyte depletion, followed by recovery of T and B cells with regulatory phenotypes. Alemtuzumab is capable of complement-dependent cytotoxicity and antibody-dependent cell-mediated cytotoxicity (ADCC), as well as induction of apoptosis. Alemtuzumab has the potential for B-cell chronic lymphocytic leukaemia research[1][2].

体内研究
(In Vivo)

Alemtuzumab (Campath-IH；0.5-5 mg/kg；腹腔注射；单剂量) 会导致外周血和淋巴器官中 B 和 T 淋巴细胞的剂量依赖性消耗[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: hCD52 transgenic mice[2]
Dosage: 0.5-5 mg/kg
Administration: IP; a single dose
Result: Resulted in the dose-dependent depletion of B and T lymphocytes in the peripheral blood and lymphoid organs.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

阿伦单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 97.15%

COA (172 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Alemtuzumab 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

Alemtuzumab216503-57-0Campath-IH阿伦单抗ApoptosisCD52myeloid cell typeslymphocyte depletionT cellsB cellsInhibitorinhibitorinhibit

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