1. TGF-beta/Smad Stem Cell/Wnt
  2. TGF-β Receptor TGF-beta/Smad
  3. ALK5-IN-32

ALK5-IN-32 (化合物 EX-09) 是一种选择性的 ALK-5 抑制剂 (10 nM<IC50<100 nM),能抑制 TGF-β 诱导的 SMAD 信号传导。ALK5-IN-32 有抑制体内肿瘤生长的潜力。ALK5-IN-32 可用于增殖性疾病,如癌症、纤维化疾病、系统性硬化症的研究。

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ALK5-IN-32 Chemical Structure

ALK5-IN-32 Chemical Structure

CAS No. : 2785430-88-6

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ALK5-IN-32 (compound EX-09) is a selective ALK-5 inhibitor (10 nM<IC50<100 nM), inhibits TGF-β-induced SMAD signaling. ALK5-IN-32 has the potential to inhibit growth of tumour in vivo. ALK5-IN-32 can be used in study of proliferative diseases such as cancer, fibrotic diseases, and systemic sclerosis[1].

IC50 & Target

ALK-5[1].

分子量

430.48

Formula

C23H23FN8

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
ALK5-IN-32
目录号:
HY-151282
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