2. Immunology/Inflammation
  3. Mesothelin
  4. Amatuximab

Amatuximab  (Synonyms: MORab-009)

目录号: HY-P99006 纯度: 99.90%
COA

摩尔计算器

Amatuximab (MORab-009) 是一种针对细胞表面间皮素 (MSLN) 的嵌合人源化 IgG1/k 单抗。Mesothelin 是一种糖基磷脂酰肌醇 (GPI) 锚定的膜糖蛋白，存在于有限的正常成人组织中，如间皮。

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Amatuximab Chemical Structure

Amatuximab Chemical Structure

CAS No. : 931402-35-6

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规格 价格 是否有货 数量
1 mg ￥2500
In-stock
5 mg ￥6500
In-stock
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Customer Review

Amatuximab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Amatuximab (MORab-009) is a chimeric, humanized IgG1/k MAb that targets the cell surface mesothelin (MSLN). Mesothelin is a glycosylphosphatidyl inositol (GPI)-anchored membrane glycoprotein, which is present in a restricted set of normal adult tissues such as the mesothelium[1][2].

体外研究
(In Vitro)

Amatuximab (MORAb-009) 是一种鼠-人嵌合单克隆抗体，对 MSLN 具有选择性亲和力。在体外，Amatuximab 可引发针对表达间皮素的肿瘤细胞系的抗体依赖性细胞毒性 (ADCC)，并抑制间皮素阳性肿瘤细胞与表达 CA125 的肿瘤细胞的异型细胞粘附[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Amatuximab 相关抗体:
体内研究
(In Vivo)

在肿瘤异种移植研究中，与单独使用阿妥昔单抗或化疗相比，使用阿妥昔单抗和化疗联合处理可更大程度地减少表达间皮素的肿瘤的生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 99.90%

COA (172 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Amatuximab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amatuximab931402-35-6MORab-009MORab009MORab 009MesothelinMSLNmesothelinMAbGPIantibody-dependent cellular cytotoxicityADCCInhibitorinhibitorinhibit

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