2. Anti-infection
  3. SARS-CoV
  4. Amubarvimab

Amubarvimab  (Synonyms: BRII-196)

目录号: HY-P99435 纯度: 95.00%
COA

摩尔计算器

Amubarvimab (BRII-196) 是一种人 IgG1 mAb，可结合刺突蛋白受体结合域 (RBD) 上的非竞争表位，KD 为 5.88 nM。Amubarvimab 可有效中和 SARS-CoV-2 变异体。

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Amubarvimab Chemical Structure

Amubarvimab Chemical Structure

CAS No. : 2509447-07-6

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规格 价格 是否有货 数量
1 mg ￥3500
In-stock
5 mg ￥9100
In-stock
10 mg   询价  
50 mg   询价  

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Customer Review

Amubarvimab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Amubarvimab (BRII-196) is a human IgG1 mAb that bind to non-competing epitopes on the receptor binding domain (RBD) of spike protein, with a KD of 5.88 nM. Amubarvimab can effectively neutralize SARS-CoV-2 variants[1][2].
体外研究
(In Vitro)

Amubarvimab 对野生型 SARS-CoV-2 具有特异性活性，并且与其他冠状病毒无交叉反应[1]。
Amubarvimab 结合两个区域，跨越受体结合基序 (RBM) 中的氨基酸 453-505 和 RBD 核心区域中的氨基酸残基 403-421[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Amubarvimab 相关抗体:
体内研究
(In Vivo)

Amubarvimab (10-50 mg/kg; i.p.) 与 Romusevimab 联合给药可显着降低 SARS-CoV-2 感染的叙利亚金仓鼠肺部病毒载量，并减轻肺部病变[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Amubarvimab 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amubarvimab2509447-07-6BRII-196BRII196BRII 196SARS-CoVSARS coronavirusIgG1receptor binding domainRBDspike proteinSARS-CoV-2Inhibitorinhibitorinhibit

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