1. Inhibitory Antibodies
  2. Anifrolumab

Anifrolumab 

目录号: HY-P99168 纯度: 99.48%
COA

Anifrolumab 是一种 I 型干扰素 (IFN) 受体拮抗剂,是一种人源单克隆抗体。Anifrolumab 能阻断 I 型干扰素的活性,可用于系统性红斑狼疮 (SLE) 的研究。

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Anifrolumab Chemical Structure

Anifrolumab Chemical Structure

CAS No. : 1326232-46-5

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anifrolumab is a type I interferon (IFN) receptor antagonist, a human monoclonal antibody. Anifrolumab blocks the activity of type I interferon. Anifrolumab can be used in systemic lupus erythematosus (SLE) research[1][2].

体外研究
(In Vitro)

Anifrolumab (67.7 nM; 20 min) induces sustained reduction of surface IFNAR1 and abrogates STAT1 phosphorylation[2].
Anifrolumab (1 and 10 μg/mL; 6 or 7 d) suppresses differentiation of B cells into plasma cells[2].
Anifrolumab inhibits type I IFN-induced ISRE signaling, with IC50s ranging from 0.004 to 0.3 nM for the IFN-α subtypes, and 0.03 nM and 0.07 nM for IFN-β and IFN-ω, respectively[2].
Anifrolumab (67.7 nM) dose-dependently inhibits IFN-α production from pDCs in response to CpG-A or DNA-IC stimulation, inhibiting 87-95% of IFN-α production[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: Peripheral blood mononuclear cells (PBMCs)
Concentration: 67.7 nM
Incubation Time: 20 min
Result: Abrogated IFN-α2-dependent and pDC supernatant-dependent STAT1 phosphorylation.

Cell Differentiation Assay[2]

Cell Line: Plasmacytoid dendritic cell (pDC)
Concentration: 1 and 10 μg/mL
Incubation Time: 6 or 7 days
Result: Inhibited pDC-mediated plasma cell differentiation in a dose-dependent manner, with a mean 76% reduction in plasma cell number relative to control antibody.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

纯度: 99.48%

参考文献
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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Anifrolumab
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HY-P99168
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