2. Immunology/Inflammation
  3. CD2
  4. Anti-CD2 Antibody (CB.219)

Anti-CD2 Antibody (CB.219) 

目录号: HY-P990868
技术支持

Anti-CD2 Antibody (CB.219) 是一种抗人 CD2 IgG2b 单克隆抗体。Anti-CD2 Antibody (CB.219) 可以减少 T 细胞、巨噬细胞的浸润和结肠中 Treg 的数量。Anti-CD2 Antibody (CB.219) 可用于弓形虫感染和结肠炎等感染和炎症的研究。Anti-CD2 Antibody (CB.219) 的同型对照为 Mouse IgG2b kappa, Isotype Control (HY-P99982)。

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Anti-CD2 Antibody (CB.219)

Anti-CD2 Antibody (CB.219) Chemical Structure

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Anti-CD2 Antibody (CB.219) 相关抗体

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  • 生物活性

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生物活性

Anti-CD2 Antibody (CB.219) is an anti-human CD2 IgG2b monoclonal antibody. Anti-CD2 Antibody (CB.219) can reduce the infiltration of T cells, macrophages, and the number of Tregs in the colon. Anti-CD2 Antibody (CB.219) can be used for research on infection and inflammation such as toxoplasma infection and colitis. The recommend isotype control of Anti-CD2 Antibody (CB.219): Mouse IgG2b kappa, Isotype Control (HY-P99982)[1][2].

同型

Mouse IgG2b kappa
推荐同型对照抗体
反应种属

Human
IC50 & Target

CD2
体内研究
(In Vivo)

Anti-CD2 Antibody (CB.219) (200 μg，腹腔注射，在第 0、3 和 5 天) 显著减少了感染弓形虫株 ME49 的人 CD2 转基因小鼠中调节性 T 细胞 (Tregs) 的数量[1]。
Anti-CD2 Antibody (CB.219) (200 μg，腹腔注射，每 3 天一次) 显著提高了结肠炎 Rag1-ko 小鼠的存活率并减少了炎症[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: T. gondii strain ME49 infected human CD2 transgenic mice[1]
Dosage: 200 μg
Administration: Intraperitoneal injection (i.p.), on day 0, 3 and 5
Result: Did not affect parasite clearance or the degree of small intestinal inflammation.
Reduced the levels of IFNγ, TGFβ, and IL-6 in the small intestine and liver.
Significantly reduced the number of FoxP3+Tregs in the small intestine and liver.
Did not affect the infiltration or activation status of neutrophils, macrophages, and T cells.
Animal Model: Rag1-ko mice with a colitis model[2]
Dosage: 200 μg
Administration: Intraperitoneal injection (i.p.), once every 3 days
Result: Significantly improved survival rate and alleviated colitis symptoms in concurrent treatment group.
Reduced T cell infiltration and epithelial damage in concurrent treatment group.
Reversed colitis, improved clinical symptoms and histopathology, and reduced the expression of pro-inflammatory cytokines in therapeutic treatment group.
基因 ID

12481  [NCBI]

Accession

NP_038514.1
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-CD2 Antibody (CB.219) 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-CD2 Antibody (CB.219)CD2Cluster of differentiation 2T cellsTregstoxoplasmacolitisInhibitorinhibitorinhibit

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