2. Immunology/Inflammation
  3. CD28
  4. Anti-Mouse CD28 Antibody (37.51)

Anti-Mouse CD28 Antibody (37.51) 

目录号: HY-P99123 纯度: 95.00%
COA 技术支持

Anti-Mouse CD28 Antibody (37.51) 是一种源自叙利亚仓鼠宿主的一种激动型 CD28 特异性抗体。Anti-Mouse CD28 Antibody (37.51) 通过选择性清除小鼠体内的同种异体反应性 T 细胞，部分预防致死性移植物抗宿主病 (GVHD)。

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Anti-Mouse CD28 Antibody (37.51)

Anti-Mouse CD28 Antibody (37.51) Chemical Structure

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规格 价格 是否有货 数量
1 mg ￥2200
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Anti-Mouse CD28 Antibody (37.51) 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse CD28 Antibody (37.51) is an agonistic agonistic CD28-specific antibody derived from the host Syrian Hamster. Anti-Mouse CD28 Antibody (37.51) partially prevents lethal graft-versus-hostdisease (GVHD) by selective depletion of alloreactive T cells in mice[1].

同型

Syrian hamster IgG2
反应种属

Mouse
IC50 & Target

CD28
体内研究
(In Vivo)

Anti-Mouse CD28 Antibody (37.51) (100 μg 单次给药或 20 μg 每隔一天给药一次，共 8 次，腹腔注射) 可在 T 细胞充足的骨髓移植清髓小鼠模型中预防移植物抗宿主病 (GVHD) 导致的死亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Lethally irradiated (1200 cGy) B10.BR mice were given transplants of 15 x 106 T cell–depleted marrow cells plus 25 x 106 splenocytes from B6 donors[1]
Dosage: 20 μg and 100 μg for a single dose, 20 μg every other day for 8 times
Administration: Intraperitoneally injection
Result: Delayed the onset of GVHD and improved survival after a single 20-μg dose.
Protected 60% of mice from lethal acute GVHD after a single 100-μg dose.
Resulted of 20 μg administered every other day for 8 days similar to those with a single 100-μg dose.
Decreased donor CD4+ cells and CD8+ cells.
Reduced numbers of T- and B- cells in the spleen.
基因 ID

12487  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 95.00%

COA (268 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse CD28 Antibody (37.51) 相关分类

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD28 Antibody (37.51)CD28T cellsGVHDInhibitorinhibitorinhibit

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