2. Apoptosis
  3. Transferrin Receptor
  4. Anti-Mouse CD71/TfR1 Antibody (8D3)

Anti-Mouse CD71/TfR1 Antibody (8D3) 

目录号: HY-P990129 纯度: 95.00%
COA 技术支持

Anti-Mouse CD71/TfR1 Antibody (8D3) 是一种源自大鼠的抗小鼠 CD71/TfR1 IgG2a 型抗体抑制剂。Anti-Mouse CD71/TfR1 Antibody (8D3) 可以消耗 CD71 阳性红系细胞，但不会改变新生小鼠中调节性 T (Tregs) 细胞的比例。Anti-Mouse CD71/TfR1 Antibody (8D3) 能增强新生小鼠对感染的防御能力。

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Anti-Mouse CD71/TfR1 Antibody (8D3)

Anti-Mouse CD71/TfR1 Antibody (8D3) Chemical Structure

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Anti-Mouse CD71/TfR1 Antibody (8D3) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse CD71/TfR1 Antibody (8D3) is a rat-derived anti-mouse CD71/TfR1 IgG2a type antibody inhibitor. Anti-Mouse CD71/TfR1 Antibody (8D3) depletes of CD71+ erythroid cells but does not change percentages of Tregs in neonatal mice. Anti-Mouse CD71/TfR1 Antibody (8D3) enhances neonatal mice defence against infection[1][2].

同型

Rat IgG2a kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

CD71/TfR1
体外研究
(In Vitro)

抗体框架具有稳定性、特异性和适应性，同时具有结合抗原和内源免疫受体。 单克隆抗体具有几种衍生物，包括双特异性抗体、抗体-药物缀合物和抗体片段，在免疫学和肿瘤学等领域具有显著效果。 设计抑制性抗体时，需要注意包括抗原特异性可变区的鉴定、表达系统的选择、多特异性形式的使用以及基于片段化、寡聚化或与其他功能部分缀合的抗体衍生物[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD71/TfR1 Antibody (8D3) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse CD71/TfR1 Antibody (8D3) (150 μg，腹腔注射，出生后第 5、6 天) 增强新生小鼠对感染的防御能力[1]。
Anti-Mouse CD71/TfR1 Antibody (8D3) (150 μg，腹腔注射，出生后第 9 天) 消耗 CD71 阳性红系细胞，但不改变新生小鼠调节性 T 细胞 (Tregs) 的百分比[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8-day-old neonatal mice [1]
Dosage: 150 μg
Administration: Intraperitoneally injection at days 5 and 6 after birth
Result: Significant reduced the number of recoverable L. monocytogenes bacteria.
Significantly produced more TNF-α and upregulated expression of the co-stimulatorymolecules CD40, CD80 and CD86.
Restored neonatal resistance to E. coli infection.
Animal Model: Neonatal mice [2]
Dosage: 150 μg
Administration: Intraperitoneally injection at day 9 after birth
Result: Reduced approximately 60% of CD71+ erythroid cells in the spleen of mice.
Had no significant effects on the percentage of Tregs.
Significantly up-regulated VISTA expression in both the percentages and MFI of VISTA expression.
Upregulated Id1 and Id2 genes and produced TGF-β.
基因 ID

64678  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 95.00%

COA (268 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse CD71/TfR1 Antibody (8D3) 相关分类

  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD71/TfR1 Antibody (8D3)Transferrin ReceptorTfRCD71TfR1TregsInfectionInhibitorinhibitorinhibit

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