2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. Anti-Mouse CD8 beta Antibody (53-5.8)

Anti-Mouse CD8 beta Antibody (53-5.8) 

目录号: HY-P99128 纯度: ≥95.0%
COA 技术支持

Anti-Mouse CD8 beta Antibody (53-5.8) 是一种抗小鼠 CD8 beta IgG2a 单克隆抗体。Anti-Mouse CD8 beta Antibody (53-5.8) 可以耗竭 CD8+ T 细胞并增强细胞毒性。Anti-Mouse CD8 beta Antibody (53-5.8) 可用于免疫学研究。

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Anti-Mouse CD8 beta Antibody (53-5.8)

Anti-Mouse CD8 beta Antibody (53-5.8) Chemical Structure

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规格 价格 是否有货 数量
1 mg ￥680
In-stock
5 mg ￥2700
In-stock
10 mg ￥4600
In-stock
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Anti-Mouse CD8 beta Antibody (53-5.8) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse CD8 beta Antibody (53-5.8) is an anti-mouse CD8 beta IgG2a monoclonal antibody. Anti-Mouse CD8 beta Antibody (53-5.8) can deplete CD8+ T cells and enhance cytotoxicity. Anti-Mouse CD8 beta Antibody (53-5.8) can be used for research on immunology[1][2].

同型

Rat IgG1 kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

CD8 beta
体外研究
(In Vitro)

Anti-Mouse CD8 beta Antibody (53-5.8) (0.1-10 μg/mL, 1-2 小时) 在低浓度 (0.1 μg/mL) 下增强 OT1 CD8+ T 的细胞毒性，在高浓度 (> 1 μg/mL) 时显著抑制杀伤功能[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD8 beta Antibody (53-5.8) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse CD8 beta Antibody (53-5.8) (10 mg/kg，腹腔注射，每周一次，治疗结束后) 可耗竭患有自发性 HER2 驱动的乳腺癌症的 SCID-beige 小鼠中的 CD8+ T 细胞[1]。
Anti-Mouse CD8 beta Antibody (53-5.8) (500 μg，腹腔注射，单次剂量，在注射 CD45.1+ OT1 T 细胞后的第二天) 在 C57BL/6 小鼠中耗竭 CD8+ T 细胞并将其转化为短期效应细胞 (SLEC) 表型，并增强细胞毒性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID-beige mice (1 month) induced with Doxycycline (HY-N0565) diet (200 mg/kg)[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection (i.p.), once weekly after the end of treatment
Result: Decreased the number of CD8+ T cells.
Significantly increased the tumor recurrence rate compared to the control group.
Animal Model: C57BL/6 mice (5-10 weeks)[2]
Dosage: 500 μg
Administration: Intraperitoneal injection (i.p.), single dose, on the second day after injecting CD45.1+ OT1 T cells.
Result: Caused CD8+ T cells to exhibit the SLEC phenotype with enhanced cytotoxicity.
基因 ID

926  [NCBI]

Accession

P10966-1
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: ≥95.0%

COA (266 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse CD8 beta Antibody (53-5.8) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD8 beta Antibody (53-5.8)Transmembrane GlycoproteinCD8 betaT cellSLECInhibitorinhibitorinhibit

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目录号：
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