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  3. c-Fms
  4. Anti-Mouse CSF1R/CD115 Antibody (AFS98)

Anti-Mouse CSF1R/CD115 Antibody (AFS98) 

目录号: HY-P990125 纯度: 99.38%
COA 技术支持

Anti-Mouse (CSF1R/CD115) Antibody (AFS98) 是一种源自大鼠的抗小鼠 CSF1R IgG2a 单克隆抗体。Anti-Mouse (CSF1R/CD115) Antibody (AFS98) 通过阻断 M-CSF 与其受体的结合，抑制 M-CSF 依赖的集落形成和细胞生长。Anti-Mouse (CSF1R/CD115) Antibody (AFS98) 可用于炎症、代谢性疾病、心血管疾病和神经系统疾病的研究如中风、糖尿病和关节炎。

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Anti-Mouse CSF1R/CD115 Antibody (AFS98)

Anti-Mouse CSF1R/CD115 Antibody (AFS98) Chemical Structure

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1 mg ￥900
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5 mg ￥3600
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Anti-Mouse CSF1R/CD115 Antibody (AFS98) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse (CSF1R/CD115) Antibody (AFS98) is an anti-mouse CSF1R IgG2a antibody inhibitor derived from rats. Anti-Mouse (CSF1R/CD115) Antibody (AFS98) inhibits M-CSF-dependent colony formation and cell growth by blocking the binding of M-CSF to its receptor. Anti-Mouse (CSF1R/CD115) Antibody (AFS98) can be used for the researches of inflammation, metabolic disease, cardiovascular disease and neurological disease, such as such as stroke, diabetes and arthritis[1][2][3][4].

同型

Rat IgG2a kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

CSF1R/CD115
体外研究
(In Vitro)

抗体框架具有稳定性、特异性和适应性，同时具有结合抗原和内源免疫受体。 单克隆抗体具有几种衍生物，包括双特异性抗体、抗体-药物缀合物和抗体片段，在免疫学和肿瘤学等领域具有显著效果。 设计抑制性抗体时，需要注意包括抗原特异性可变区的鉴定、表达系统的选择、多特异性形式的使用以及基于片段化、寡聚化或与其他功能部分缀合的抗体衍生物[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CSF1R/CD115 Antibody (AFS98) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse (CSF1R/CD115) Antibody (AFS98) (MCAo 造模前 48 小时直接注射入脑) 可减少老年动物的小胶质细胞数量，但会导致缺血性中风后神经炎症增加[1]。
Anti-Mouse (CSF1R/CD115) Antibody (AFS98) (25 mg/kg，腹腔注射，两天一次，持续 6 周) 通过靶向巨噬细胞介导的损伤，抑制肥胖 (db/db) 小鼠已形成的糖尿病肾病的进展[2]。
Anti-Mouse (CSF1R/CD115) Antibody (AFS98) (2 mg/mouse，腹腔注射，两天一次，持续 6 周) 对 apoE 缺陷小鼠的早期动脉粥样硬化形成具有保护作用[3]。
Anti-Mouse (CSF1R/CD115) Antibody (AFS98) (25 or 50 mg/kg，腹腔注射，一天一次，持续 14 天) 在胶原诱导性关节炎 (CIA) 小鼠模型中显示出显著的抗炎作用[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Obese (db/db) mice models (C57BL/KS, 12 weeks)[2]
Dosage: 25 mg/kg
Administration: Intraperitoneal injections, every second day for 6 weeks
Result: Reduced renal hypertrophy, but not obesity, diabetes or circulating monocytes.
Reduced macrophage accumulation in diabetic kidneys.
Suppressed diabetic glomerular hyperfiltration without altering albuminuria.
Reduced ubular damage and tubulo-interstitial fibrosis.
Upregulated the levels of phospho-ERK, phospho-p38, phospho-JNK, phospho-ATF2 and α-tubulin.
Animal Model: ApoE-deficient mice fed a high-fat diet from 6 to 12 weeks of age[3]
Dosage: 2 mg/mouse
Administration: Intraperitoneal injections, every second day for 6 weeks
Result: Prevented development of fatty streaks.
Suppressed the accumulation of macrophage-derived foam cells in the aortic root by 70%.
Animal Model: Collagen-induced arthritis (CIA) mice models (DBA/1, male, 7-9 weeks)[4]
Dosage: 25 or 50 mg/kg
Administration: Intraperitoneal injections, every day for 14 days
Result: Inhibitd inflammatory bone and cartilage loss.
Reduced synovial joint macrophage infiltrates and splenic monocyte recruitment.
Blocked systemic bone loss by blockade of osteoclast differentiation.
Protected against bone and cartilage erosion independent of effects on inflammation in serum-transfer arthritis.
基因 ID

12978  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 99.38%

COA (268 KB) SDS-PAGE (64 KB) SEC-HPLC (167 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse CSF1R/CD115 Antibody (AFS98) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CSF1R/CD115 Antibody (AFS98)c-FmsCSF-1 receptorcolony stimulating factor 1 receptorCSF-1RCSF1RCD115StoreDiabetesCIAInhibitorinhibitorinhibit

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