2. GPCR/G Protein Immunology/Inflammation
  3. CXCR
  4. Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173)

Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) 

目录号: HY-P990254 纯度: 95.00%
COA 技术支持

Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) 是一种抗小鼠的 CXCR3/CD183 IgG 单克隆抗体。Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) 通过减少 CD4+ 和 CD8+ T 细胞的浸润来减弱免疫反应。Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) 显著延长了小鼠心脏或胰岛移植的存活时间。Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) 可用于免疫学和癌症的研究如胰腺癌。

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Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173)

Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) Chemical Structure

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Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) is an anti-mouse CXCR3/CD183 IgG monoclonal antibody. Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) weakens the immune response by reducing the infiltration of CD4+ and CD8+ T cells. Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) significantly prolongs the survival time of heart or islet transplants in mice. Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) can be used for researches on immunology and cancer such as pancreatic cancer[1][2][3].

同型

Armenian hamster IgG
推荐同型对照抗体
反应种属

Mouse
IC50 & Target[1][2][3]

mCXCR3

 

体外研究
(In Vitro)

Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) (0.001-100 μg/mL，1 小时) 有效抑制 BaF3 细胞中的配体结合 (CXCL10 抑制 60%, CXCL11 抑制 41%)[1]。
Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) (0-300 μg/mL，1 小时) 显著抑制 ConA 刺激的小鼠脾细胞中 CXCL10 (抑制 61%) 和 CXCL11 (抑制 67%) 诱导的趋化作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) (100-500 μg，腹腔注射，每隔一天一次，持续 2 周) 显著延长了 C57BL/6 (H2d) 小鼠心脏移植模型或胰岛移植模型的移植存活时间[1]。
Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) (500 μg，腹腔注射，在第 14、16、18 和 20 天) 减少了注射 mRNA-LNP 疫苗的雌性 C57BL/6 小鼠肺部 T 细胞、B 细胞和浆细胞的数量[2]。
Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) (200 μg，腹腔注射，每周两次，持续 15 天) 显著逆转了携带 KPC1199 肿瘤的雄性 C57BL/6J 野生型小鼠中 Sin3B 缺乏对肿瘤生长的抑制作用，并减少的 CD8+ T 细胞浸润[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (H2d) mice[1]
Dosage: 100, 200 and 500 μg
Administration: Intraperitoneal injection (i.p.), once every other day, for 2 weeks
Result: Significantly prolonged the survival time of the transplant to 16-18 days at a dose of 200 μg or 500 μg (compared to 6-7 days in the control group) for the heart transplantation model.
Extended the survival time of the pancreatic islet transplant from 12.5 days to 21 days.
Significantly reduced the infiltration of CD4+ and CD8+ T cells and protected the myocardial and vascular structures.
Animal Model: mRNA-LNP vaccines injected female C57BL/6 mice (6-8 weeks)[2]
Dosage: 500 μg
Administration: Intraperitoneal injection (i.p.), on day 14, 16, 18 and 20
Result: Reduced the number of CD44+Tet+CD4+/CD8+ T cells, RBD+ B cells, and IgA+ plasma cells in the lungs.
Animal Model: 1×106 KPC1199 cells injected male C57BL/6J wild-type mice[3]
Dosage: 200 μg
Administration: Intraperitoneal injection (i.p.), twice a week, for 15 days
Result: Significant increased tumor size and tumor volume.
Significantly reduced CD8+ T cell infiltration.
基因 ID

2833  [NCBI]

Accession

P49682-1
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 95.00%

COA (268 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173)CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsCXCR3/CD183T celltransplantspancreatic cancerKPC1199CD8CD4Inhibitorinhibitorinhibit

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