2. Immunology/Inflammation
  3. CD28
  4. Anti-Mouse ICOS Antibody (7E.17G9)

Anti-Mouse ICOS Antibody (7E.17G9) 

目录号: HY-P990237 纯度: 98%
COA 技术支持

Anti-Mouse ICOS Antibody (7E.17G9) 是一种抗小鼠 ICOS IgG2b 单克隆抗体。Anti-Mouse ICOS Antibody (7E.17G9) 可以上调 ICOS 表达并增强 T 细胞功能。Anti-Mouse ICOS Antibody (7E.17G9) 可以显著抑制树突状细胞 (DC) 的免疫调节功能。Anti-Mouse ICOS Antibody (7E.17G9) 可以消除移植耐受。Anti-Mouse ICOS Antibody (7E.17G9) 可用于研究炎症疾病、癌症和异种移植，如肾炎和癌症。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Anti-Mouse ICOS Antibody (7E.17G9)

Anti-Mouse ICOS Antibody (7E.17G9) Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥2000
In-stock
5 mg 现货 询价
10 mg 现货 询价
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Anti-Mouse ICOS Antibody (7E.17G9) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse ICOS Antibody (7E.17G9) is an anti-mouse ICOS IgG2b monoclonal antibody. Anti-Mouse ICOS Antibody (7E.17G9) can upregulate ICOS expression and enhance T cell function. Anti-Mouse ICOS Antibody (7E.17G9) can significantly inhibit the immune regulatory function of dendritic cells (DCs). Anti-Mouse ICOS Antibody (7E.17G9) can eliminate transplant tolerance. Anti-Mouse ICOS Antibody (7E.17G9) can be used for researches on inflammation conditions, cancer and xenotransplantation such as nephritis and pancreatic cancer[1][2][3].

同型

Rat IgG2b kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

ICOS
体外研究
(In Vitro)

Anti-Mouse ICOS Antibody (7E.17G9) (10 μg/mL，48 小时) 显著抑制 MPO/BAY 树突状细胞 (DCs) 诱导的 IL-10+ Tregs，并抑制 Tregs 活化[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse ICOS Antibody (7E.17G9) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse ICOS Antibody (7E.17G9) (250-375 μg，腹腔注射，在第 0、2、4 和 6 天) 显著降低了异位腹部心脏移植 PD-1 Tg B6 小鼠的移植耐受性[1]。
Anti-Mouse ICOS Antibody (7E.17G9) (0.2 mg，腹腔注射，每隔一天一次，从第 13 天到第 25 天) 显著抑制了 MPO 免疫模型 C57BL/6 小鼠中 IL-10+ Treg 的诱导[2]。
Anti-Mouse ICOS Antibody (7E.17G9) (100 μg，腹腔注射，在第 4、7 和 10 天) 显著延长了携带 KPC 肿瘤和 RIP1i 的 C57BL/6 小鼠的存活期[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: PD-1 Tg B6 mice (8-12 weeks)[1]
Dosage: 375 μg on day 0, 250 μg on day 2, 4 and 6
Administration: Intraperitoneal injection (i.p.), on day 0, 2, 4 and 6
Result: Significantly shortened the survival time of transplants.
Slightly increased the production of IFN-γ, but significantly reduced the production of IL-10.
Reduced IL-10 production and LAP expression in Treg cells.
Animal Model: MPO (20 μg) and CFA (HY-153808) injected C57BL/6 mice (8-12 weeks)[2]
Dosage: 0.2 mg
Administration: Intraperitoneal injection (i.p.), once every other day, from day 13 to day 25
Result: Significantly inhibited the induction of IL-10+ Tregs by MPO/BAY DCs.
Inhibited the upregulation of Foxp3, CTLA4 and TNFR2.
Animal Model: 1×105 KPC cells injected C57BL/6 mice (8-10 weeks)[3]
Dosage: 100 μg, combined with RIP1i (100 mg/kg)
Administration: Intraperitoneal injection (i.p.), on day 4, 7 and 10
Result: Upregulated ICOS expression and enhances T cell function. Significantly prolonged the survival period of mice.
基因 ID

54167  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

colorless

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-Mouse ICOS Antibody (7E.17G9) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse ICOS Antibody (7E.17G9)CD28ICOST celltransplantspancreatic cancerKPCDCsnephritisInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Anti-Mouse ICOS Antibody (7E.17G9)
目录号：
HY-P990237
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z