2. Immunology/Inflammation
  3. IFNAR
  4. Anti-Mouse IFN gamma Antibody (H22)

Anti-Mouse IFN gamma Antibody (H22) 

目录号: HY-P99136 纯度: ≥95.0%
COA 技术支持

Anti-Mouse IFN gamma Antibody (H22) 是一种源自亚美尼亚仓鼠宿主的抗小鼠 IFN gamma 的 IgG 抗体抑制剂。Anti-Mouse IFN gamma Antibody (H22) 可阻断 I25II-rIFN-γ 与巨噬细胞的特异性结合。Anti-Mouse IFN gamma Antibody (H22) 可抑制巨噬细胞活化因子 (MAF) (ID50 值为 56 ng)。Anti-Mouse IFN gamma Antibody (H22) 抑制 IFNγ 依赖性抗病毒活性 (ID50 值为 2 ng)。Anti-Mouse IFN gamma Antibody (H22) 可以中和小鼠体内的 IFNγ。Anti-Mouse IFN gamma Antibody (H22) 可以用于炎症和感染的研究，如关节炎。

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Anti-Mouse IFN gamma Antibody (H22)

Anti-Mouse IFN gamma Antibody (H22) Chemical Structure

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Anti-Mouse IFN gamma Antibody (H22) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse IFN gamma Antibody (H22) is an anti-mouse IFN gamma IgG antibody inhibitor derived from host Armenian Hamster. Anti-Mouse IFN gamma Antibody (H22) abrogates specific binding of I25II-rIFN-γ to macrophages. Anti-Mouse IFN gamma Antibody (H22) inhibits macrophage-activating factor (MAF) (ID50 = 56 ng). Anti-Mouse IFN gamma Antibody (H22) inhibits IFN-gamma dependent antiviral activity (ID50 = 2 ng). Anti-Mouse IFN gamma Antibody (H22) neutralizes IFNγ in mice. Anti-Mouse IFN gamma Antibody (H22) can be used for the researches of inflammation and infection, such as arthritis[1][2][3][4].

同型

Armenian Hamster IgG
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

IFN gamma
体外研究
(In Vitro)

Anti-Mouse IFN gamma Antibody (H22) (1 h) 可抑制巨噬细胞活化因子 (MAF) 和抗病毒活性，其 ID50 分别为 56 ng 和 2 ng[4]。
Anti-Mouse IFN gamma Antibody (H22) (50 ng, 2 h) 可阻断 I25II-rIFN-γ 与巨噬细胞的特异性结合[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse IFN gamma Antibody (H22) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse IFN gamma Antibody (H22) (200 μg，在第 0、4、11、18 天给药，共 5 次) 可中和小鼠体内的 IFNγ[1]。
Anti-Mouse IFN gamma Antibody (H22) (250 μg，在第 0、6、13、21、28、35、40 天给药，共 7 次) 可显著增加胶原诱导性关节炎小鼠模型中患关节炎的肢体数量[2]。
Anti-Mouse IFN gamma Antibody (H22) (100 μg，腹腔注射，细胞移植前 5 小时开始，每周给药一次) 完全消除了 Lyt-2+ 免疫 T 细胞对小鼠弓形虫病的保护作用[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Collagen-induced arthritis mice models (DBA/I, male, 10-12 weeks)[2]
Dosage: 250 μg
Administration: Intraperitoneally injection, at days 0, 6,13, 20, 21, 28, 35 and 42
Result: Highly increased the number of limbs affected by arthritis.
Increased clinical scores at day 45.
Increased limb involvement consistently.
Did not influence the number of mice which developed arthritis, or the time of onset of disease.
基因 ID

15978  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: ≥95.0%

COA (268 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse IFN gamma Antibody (H22) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IFN gamma Antibody (H22)IFNARInterferon-α/β receptorInterferon-alpha/beta receptorIFNArthritisMacrophagesMAFInhibitorinhibitorinhibit

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