2. Immunology/Inflammation
  3. Interleukin Related
  4. Anti-Mouse IL-12 p40 Antibody (C17.8)

Anti-Mouse IL-12 p40 Antibody (C17.8) 

目录号: HY-P990225 纯度: 95.00%
COA 技术支持

Anti-Mouse IL-12 p40 Antibody (C17.8) 是一种源自大鼠的抗小鼠 IL-12 p40 IgG2a κ 型抗体抑制剂。Anti-Mouse IL-12 p40 Antibody (C17.8) 可与 IL-12 的亚基 p40 结合。Anti-Mouse IL-12 p40 Antibody (C17.8) 可用于炎症、免疫和代谢性疾病的研究，如糖尿病和关节炎。

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Anti-Mouse IL-12 p40 Antibody (C17.8) Chemical Structure

Anti-Mouse IL-12 p40 Antibody (C17.8) Chemical Structure

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规格 价格 是否有货 数量
1 mg ￥900
In-stock
5 mg ￥3600
In-stock
10 mg ￥6150
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Anti-Mouse IL-12 p40 Antibody (C17.8) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse IL-12 p40 Antibody (C17.8) is a rat-derived anti-mouse IL-12 p40 IgG2a κ type antibody inhibitor. Anti-Mouse IL-12 p40 Antibody (C17.8) binds p40 subunit of IL-12. Anti-Mouse IL-12 p40 Antibody (C17.8) can be used for the researches of inflammation, immunology and metabolic disease, such as diabetes and arthritis[1][2][3].

同型

Rat IgG2a kappa
推荐同型对照抗体
IC50 & Target

IL-12 p40
体外研究
(In Vitro)

抗体框架具有稳定性、特异性和适应性，同时具有结合抗原和内源免疫受体。 单克隆抗体具有几种衍生物，包括双特异性抗体、抗体-药物缀合物和抗体片段，在免疫学和肿瘤学等领域具有显著效果。 设计抑制性抗体时，需要注意包括抗原特异性可变区的鉴定、表达系统的选择、多特异性形式的使用以及基于片段化、寡聚化或与其他功能部分缀合的抗体衍生物[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse IL-12 p40 Antibody (C17.8) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse IL-12 p40 Antibody (C17.8) (500 μg，腹腔注射，在第 5-30 周，每周 2 次) 可抑制非肥胖糖尿病小鼠模型中的胰岛炎和糖尿病[1]。
Anti-Mouse IL-12 p40 Antibody (C17.8) (200 μg，腹腔注射，连续 6 天) 会导致 2 周龄非肥胖糖尿病小鼠模型中的糖尿病病情加重[1]。
Anti-Mouse IL-12 p40 Antibody (C17.8) (0.5 mg，腹腔注射，在注射链球菌细胞壁 (SCW) 片段前 2 小时给药) 可抑制小鼠链球菌细胞壁诱导的关节炎[2]。
Anti-Mouse IL-12 p40 Antibody (C17.8) (0.5 mg，腹腔注射，每周 1 次) 可延长髓鞘少突胶质细胞糖蛋白诱导的实验性自身免疫性脑脊髓炎小鼠模型中小鼠的生存期[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Non-obese diabetic mice models[1]
Dosage: 500 μg
Administration: Intraperitoneally injection, twice a week during 5-30 weeks
Result: Completely prevented diabetes.
Significantly decreased the degree of insulitis.
Only 62% of NOD mice at 15 weeks of age.
Animal Model: 2-week-old non-obese diabetic mice models[1]
Dosage: 200 μg
Administration: Intraperitoneally injection, for 6 consecutive days
Result: Only 56% of NOD mice at 10 weeks of age.
Inhibited IL-2 and IFN-γ production at 4 weeks.
Enhanced production of IL-2 and IFN-γ and suppressed production of IL-4 and IL-10 at 8 weeks of age.
Increased CD25+ and CD44high cells in both CD4+ and CD8+ subsets at 8 days after the final injection.
Resulted in a rapid onset of overt diabetes when Splenic T-cells transferred to NOD-scid with spleen cells from diabetic NOD mice.
Animal Model: Streptococcal cell wall (SCW)-induced arthritis mice models[2]
Dosage: 0.5 mg
Administration: Intraperitoneally injection, 2 hours before injection of SCW fragments
Result: Increased the chondrocyte PG synthesis.
Reduced infiltration of synovial membrane with inflammatory cells.
Decreased mRNA levels for IL1β, IL12 and TNFα and increased IL1Ra and IL10 mRNA levels.
Animal Model: B6D2F1 mice were injected with 80 million B6 spleen cells[3]
Dosage: 0.5 mg
Administration: Intraperitoneally injection, every 7 days subsequently
Result: Significantly prolonged survival of mice.
基因 ID

16159  [NCBI] & 16160  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 95.00%

COA (267 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse IL-12 p40 Antibody (C17.8) 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IL-12 p40 Antibody (C17.8)Interleukin RelatedILIL-12P40InflammationImmunologyDiabetesArthritisInhibitorinhibitorinhibit

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