2. Immunology/Inflammation
  3. Interleukin Related
  4. Anti-Mouse IL-23 p19 Antibody (G23-8)

Anti-Mouse IL-23 p19 Antibody (G23-8) 

目录号: HY-P990217 纯度: ≥95.0%
COA 技术支持

Anti-Mouse IL-23 p19 Antibody (G23-8) 是一种大鼠来源的抗小鼠 IL-23 p19 IgG1 单克隆抗体。Anti-Mouse IL-23 p19 Antibody (G23-8) 通过恢复 CLDN8 表达来减轻炎症。Anti-Mouse IL-23 p19 Antibody (G23-8) 可用于研究结肠炎和哮喘等炎症疾病。

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Anti-Mouse IL-23 p19 Antibody (G23-8) Chemical Structure

Anti-Mouse IL-23 p19 Antibody (G23-8) Chemical Structure

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10 mg ￥9900
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Anti-Mouse IL-23 p19 Antibody (G23-8) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse IL-23 p19 Antibody (G23-8) is a rat-derived anti-mouse IL-23 p19 IgG1 monoclonal antibody. Anti-Mouse IL-23 p19 Antibody (G23-8) alleviates inflammation by restoring CLDN8 expression. Anti-Mouse IL-23 p19 Antibody (G23-8) can be used for research on inflammation conditions such as colitis and asthma[1][2].

IC50 & Target[1][2]

IL-23

 

体外研究
(In Vitro)

Anti-Mouse IL-23 p19 Antibody (G23-8) (6 μg/mL, 72 小时) 逆转了 NCM460 和 Caco-2 细胞中 IL23 介导的 CLDN8 表达的显著下调[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse IL-23 p19 Antibody (G23-8) 相关抗体:

RT-PCR[1]

Cell Line: NCM460 and Caco-2 cells
Concentration: 6 μg/mL
Incubation Time: 72 h
Result: Reversed the significant downregulation of the CLDN8 mRNA level by IL23.

Western Blot Analysis[1]

Cell Line: NCM460 and Caco-2 cells
Concentration: 6 μg/mL
Incubation Time: 72 h
Result: Reversed the significant downregulation of the CLDN8 protein level by IL23.
体内研究
(In Vivo)

Anti-Mouse IL-23 p19 Antibody (G23-8) (0.5 mg/kg, 腹腔注射, 每天一次, 持续 3 天) 可减少 Trinitrobenzene sulfonic acid (TNBS) 诱导的雄性 BALB/c 小鼠的肠道炎症并增加肠道通透性[1]。
Anti-Mouse IL-23 p19 Antibody (G23-8) (400 μg/鼠, 腹腔注射, 在激发前 1 小时, 在第14, 15, 21 和 22 天) 抑制用 Ovalbumin (OVA) 或屋尘螨 (HDM) 诱导的雄性 C57BL/6 小鼠的 Th17 激活和中性粒细胞炎症[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/c mice (6-8 weeks) induced with Trinitrobenzene sulfonic acid (TNBS)[1]
Dosage: 0.5 mg/kg
Administration: Intraperitoneal injection (i.p.), once daily, for 3 days
Result: Significantly alleviated intestinal inflammation.
Restored the expression of CLDN8.
Improved weight and histological score.
Increased intestinal permeability and alleviated myeloperoxidase (MPO) activity.
Animal Model: Male C57BL/6 mice induced with OVA or HDM[2]
Dosage: 400 μg/mouse
Administration: Intraperitoneal injection (i.p.), 1 h before every challenge period on day 14, 15, 21, and 22
Result: Inhibited Th17 activation and neutrophilic inflammation.
基因 ID

83430  [NCBI] & 16160  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: ≥95.0%

COA (267 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse IL-23 p19 Antibody (G23-8) 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IL-23 p19 Antibody (G23-8)Interleukin RelatedILIL-23p19colitisasthmaInhibitorinhibitorinhibit

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