2. Immunology/Inflammation Anti-infection
  3. Interleukin Related Parasite
  4. Anti-Mouse IL-3 Antibody (MP2-8F8)

Anti-Mouse IL-3 Antibody (MP2-8F8) 

目录号: HY-P990214 纯度: 95.00%
COA 技术支持

Anti-Mouse IL-3 Antibody (MP2-8F8) 是一种抗小鼠 IL-3 IgG1 单克隆抗体。Anti-Mouse IL-3 Antibody (MP2-8F8) 通过减少滑膜白细胞浸润和细胞因子水平来缓解关节炎症。Anti-Mouse IL-3 Antibody (MP2-8F8) 可以减少嗜碱性粒细胞的积聚。Anti-Mouse IL-3 Antibody (MP2-8F8) 可用于研究炎症或感染疾病，如关节炎和寄生虫感染。

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Anti-Mouse IL-3 Antibody (MP2-8F8)

Anti-Mouse IL-3 Antibody (MP2-8F8) Chemical Structure

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Anti-Mouse IL-3 Antibody (MP2-8F8) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse IL-3 Antibody (MP2-8F8) is an anti-mouse IL-3 IgG1 monoclonal antibody. Anti-Mouse IL-3 Antibody (MP2-8F8) relieves joint inflammation by reducing synovial leukocyte infiltration and cytokine levels. Anti-Mouse IL-3 Antibody (MP2-8F8) can reduce the accumulation of basophils. Anti-Mouse IL-3 Antibody (MP2-8F8) can be used for researches on inflammation or infection conditions such as arthritis and parasitic infections[1][2][3].

同型

Rat IgG1
推荐同型对照抗体
反应种属

Mouse
IC50 & Target[1][2][3]

IL-3

 

体外研究
(In Vitro)

Anti-Mouse IL-3 Antibody (MP2-8F8) (10 μg/mL，24 小时) 显著降低了骨髓源性肥大细胞 (BMMC) 中 ICOS-L 的表达。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse IL-3 Antibody (MP2-8F8) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse IL-3 Antibody (MP2-8F8) (35 或 50 μg，腹腔注射，每天一次，持续 7 或 15 天) 可以显著改善患有牛 II 型胶原 (CII) (HY-NP102) 诱导的关节炎雄性 DBA/1 小鼠的关节炎症状[1]。
Anti-Mouse IL-3 Antibody (MP2-8F8) (2 mg，腹腔注射，每 3 天一次) 可减少感染寄生虫感染模型的 Rag2-/- 小鼠后肝脏中嗜碱性粒细胞的积聚[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CII (100-200 μg) induced male DBA/1 mice[1]
Dosage: 35 μg for early blockade, 50 for late blockade
Administration: Intraperitoneal injection (i.p.), once daily, 15 days for early blockade or 7 days for late blockade
Result: Significantly reduced the score of arthritis, synovitis, and antibody titers for early blockade.
Had no significant impact on arthritis for late blockade.
Animal Model: Rag2-/- mice injected with 600 third stage infectious larvae of Nippostrongylus brasiliensis[3]
Dosage: 2 mg
Administration: Intraperitoneal injection (i.p.), once every 3 days
Result: Reduced eosinophils to 14 %.
基因 ID

16187  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 95.00%

COA (268 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse IL-3 Antibody (MP2-8F8) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IL-3 Antibody (MP2-8F8)Interleukin RelatedParasiteILIL-3basophilsparasiticarthritisInhibitorinhibitorinhibit

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