2. GPCR/G Protein Neuronal Signaling NF-κB Stem Cell/Wnt JAK/STAT Signaling
  3. Neurokinin Receptor NF-κB STAT
  4. Anti-Mouse NK1.1 Antibody (PK136)

Anti-Mouse NK1.1 Antibody (PK136) 

目录号: HY-P99143 纯度: ≥95.0%
COA 技术支持

Anti-Mouse NK1.1 Antibody (PK136) 是一种抗小鼠 NK1.1 IgG2a 单克隆抗体。Anti-Mouse NK1.1 Antibody (PK136) 可以耗竭自然杀伤 (NK) 细胞。Anti-Mouse NK1.1 Antibody (PK136) 抑制 JAK-STAT 和 NF-κB 信号通路。Anti-Mouse NK1.1 Antibody (PK136) 可用于研究炎症疾病，如非酒精性脂肪性肝炎 (NASH)。

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Anti-Mouse NK1.1 Antibody (PK136)

Anti-Mouse NK1.1 Antibody (PK136) Chemical Structure

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5 mg ￥3600
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Anti-Mouse NK1.1 Antibody (PK136) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse NK1.1 Antibody (PK136) is an anti-mouse NK1.1 IgG2a monoclonal antibody. Anti-Mouse NK1.1 Antibody (PK136) can deplete natural killer (NK) cells. Anti-Mouse NK1.1 Antibody (PK136) inhibits the JAK-STAT and NF-κB signaling pathways. Anti-Mouse NK1.1 Antibody (PK136) can be used for research on inflammation conditions such as non-alcoholic steatohepatitis (NASH)[1][2].

同型

Mouse IgG2a kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target[2]

NF-κB

 

p-STAT3

 

STAT1

 

体内研究
(In Vivo)

Anti-Mouse NK1.1 Antibody (PK136) (90 µg，在肿瘤植入前第 1 天和接种 Panc02 细胞后第 1、4、7、14、21 天) 可以减少携带 Panc02 肿瘤的雄性 C57BL/6 小鼠的自然杀伤 (NK) 细胞数量[1]。
Anti-Mouse NK1.1 Antibody (PK136) (150 μg，腹腔注射，每3天一次，从第 7 周到第 11 周) 可以改善喂食蛋氨酸和胆碱缺乏 (MCD) 饮食的雄性 C57BL/6 小鼠的非酒精性脂肪性肝炎(NASH) [2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5×105 Panc02 cells injected male C57BL/6 mice (6 weeks)[1]
Dosage: 90 µg
Administration: /, on day 1 before tumor engraftment and on day 1, 4, 7, 14, 21 after Panc02 cells inoculation
Result: Significantly reduced the number of NK cells.
Significantly increased tumor weight.
Animal Model: Male C57BL/6 mice (6-8 weeks) fed with MCD diet (4 weeks)[2]
Dosage: 150 μg
Administration: Intraperitoneal injection (i.p.), once every 3 days from week 7 to week 11
Result: Significantly reduced the number of NK cells.
Ruduced the level of p-STAT1, p-STAT3, and p-NF-κB p65.
Improved NASH inflammation in mice.
基因 ID

17057  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: ≥95.0%

COA (268 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse NK1.1 Antibody (PK136) 相关分类

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse NK1.1 Antibody (PK136)Neurokinin ReceptorNF-κBSTATNK receptorTachykinin receptorNuclear factor-κBNuclear factor-kappaBNK1.1NASHInhibitorinhibitorinhibit

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