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  4. Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10)

Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10) 

目录号: HY-P990117 纯度: ≥95.0%
COA 技术支持

Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10) 是一种源自小鼠的 Osteopontin/SPP11 IgG1 κ 型抗体抑制剂。Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10) 可阻断心脏成纤维细胞中 Angiotensin II (HY-13948) 诱导的DNA 合成和胶原凝胶收缩。Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10) 能显著抑制 CT26 或 MC38 小鼠肿瘤模型中的肿瘤生长 。

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Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10)

Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10) Chemical Structure

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Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10) 相关抗体

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10) is a mouse-derived Osteopontin/SPP1 IgG1 κ type antibody inhibitor. Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10) blocks Angiotensin II (HY-13948)-induced DNA synthesis and collagen gel contraction in cardiac fibroblasts. Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10) significantly inhibits tumor growth in CT26 or MC38 tumors mice models[1][2][3].

同型

Mouse IgG1 kappa
推荐同型对照抗体
反应种属

Human/Mouse/Rat
IC50 & Target

Osteopontin/SPP1
体外研究
(In Vitro)

Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10) (7.2 μg/mL or 72 ng/mL, 30 min) 可阻断心肌成纤维细胞中 Angiotensin II (HY-13948) 诱导的 DNA 合成[2]。
Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10) (7.2 μg/mL or 25 μg/mL, 30 min) 可阻断心肌成纤维细胞中 Angiotensin II 和 osteopontin 诱导的中胶原凝胶收缩[2]。
Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10) (100 ng/mL, 48 h) 显著减弱 A10 细胞中高迁移率族蛋白 B1 (HMGB1) 诱导的血管平滑肌细胞 (VSMC) 迁移[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10) (500 μg/mouse，腹腔注射，两天一次，持续 10 天) 能显著抑制CT26 或 MC38 小鼠肿瘤模型中的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: The mice were subcutaneously injected with CT26 or MC38 tumors (3 x 105 cells) on day 0 and some mice were also given a B-cell–based vaccine on day 9 (MC38 model) or day 10 (CT26 model) (Balb/c or C57BL/6)[1]
Dosage: 500 μg/mouse
Administration: Intraperitoneally injection, every other day for 10 days
Result: Significantly inhibited tumor growth.
Significantly delayed tumor growth in mice treated with the B-cell–based vaccine.
基因 ID

20750  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: ≥95.0%

COA (268 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10)IntegrinOsteopontinSPP1Cardiac fibroblastsAngiotensin IIHMGB1CanerCT26 cellsMC38 cellsInhibitorinhibitorinhibit

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