2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. Anti-Mouse Siglec-H Antibody (440c)

Anti-Mouse Siglec-H Antibody (440c) 

目录号: HY-P990163
技术支持

Anti-Mouse Siglec-H Antibody (440c) 是一种源自大鼠的 IgG2b 型抗体抑制剂，靶向小鼠 Siglec-H。Anti-Mouse Siglec-H Antibody (440c) 可识别选择性表达于浆细胞样树突状细胞和干扰素产生细胞上的唾液酸结合免疫球蛋白 (Ig) 样凝集素家族 (Siglec-H)。Anti-Mouse Siglec-H Antibody (440c) 可用于炎症和免疫学研究，如结肠炎。

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Anti-Mouse Siglec-H Antibody (440c)

Anti-Mouse Siglec-H Antibody (440c) Chemical Structure

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Anti-Mouse Siglec-H Antibody (440c) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse Siglec-H Antibody (440c) is a rat-derived IgG2b type antibody inhibitor, targeting to mouse Siglec-H. Anti-Mouse Siglec-H Antibody (440c) recognizes sialic acid-binding immunoglobulin (Ig)-like lectin family (Siglec-H) selectively expressing on plasmacytoid DCs and interferon–producing cells. Anti-Mouse Siglec-H Antibody (440c) can be used for the researches of inflammation and immunology, such as colitis[1][2].

同型

Rat IgG2b
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

Siglec-H
体外研究
(In Vitro)

Anti-Mouse Siglec-H Antibody (440c) (24 h) 可阻断小鼠干扰素产生细胞分泌 IFN-α[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse Siglec-H Antibody (440c) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse Siglec-H Antibody (440c) (200 μg，腹腔注射，每 24 小时一次，共 1-2 次) 可降低 129/SvJ 小鼠血清中 IFN-α 水平，且不会耗竭产生干扰素的细胞[1]。
Anti-Mouse Siglec-H Antibody (440c) (200 μg，腹腔注射，隔天一次) 可阻断硫酸葡聚糖钠 (DSS) (HY-116282C) 诱导的结肠炎模型小鼠中浆细胞样树突状细胞对 Toll 样受体刺激的功能反应并阻断 GM-CSF 的治疗作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Dextran sulphate sodium (DSS) (HY-116282C)-induced colitis mice models[2]
Dosage: 200 μg
Administration: Intraperitoneally injection, every other day companied with GM-CSF
Result: Blocked the plasmacytoid DCs functional response to Toll like receptors stimulation and therapeutic effects of GM-CSF.
基因 ID

233274  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-Mouse Siglec-H Antibody (440c) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse Siglec-H Antibody (440c)Transmembrane GlycoproteinSiglec-HPlasmacytoid DCsInterferon–producing cellsColitisIFN-αDextran sulphate sodiumInhibitorinhibitorinhibit

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