2. Immunology/Inflammation
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  4. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5)

Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) 

目录号: HY-P99146 纯度: ≥95.0%
COA 技术支持

Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) 是一种抗小鼠 TCR gamma/delta IgG 单克隆抗体。Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) 可以透过血脑屏障。Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) 有效地耗竭 γδ T 细胞并减少巨噬细胞和中性粒细胞的浸润。Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) 可以降低移植物的免疫反应。Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) 可用于研究炎症疾病、病毒感染和癌症，如关节炎、JHM 病毒和乳腺癌。

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Anti-Mouse TCR gamma/delta Antibody (UC7-13D5)

Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) Chemical Structure

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1 mg ￥2150
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5 mg ￥5800
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Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) is an anti-mouse TCR gamma/delta IgG monoclonal antibody. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) can enter the blood-brain barrier. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) effectively depletes γδ T cells and reduces macrophage and neutrophil infiltration. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) can reduce the immune response of transplants. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) can be used for researches on inflammation conditions, virus infection and cancer such as arthritis, JHM virus and breast cancer[1][2][3].

同型

Armenian Hamster IgG
推荐同型对照抗体
反应种属

Mouse
体外研究
(In Vitro)

Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) (200 μg，2 天) 显著减少了小鼠脾脏和淋巴结中 γδ T 细胞的数量[2]。
Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) (5 μg/mL，48 小时) 可增强 γδ T 细胞中 IFN-γ 的产生[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) 相关抗体:

ELISA Assay[3]

Cell Line: γδ T cells
Concentration: 5 μg/mL, co-incubation with PSK (100 μg/mL)
Incubation Time: 48 h
Result: Significantly increased the level of IFN-γ to 12823 pg/mL.
体内研究
(In Vivo)

Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) (250 μg，腹腔注射，在第 0、3、6、9 和 12 天) 在感染 JHM 病毒的 TCRβ-/- 小鼠中耗尽中枢神经系统 (CNS) 中的 γδ T 细胞[1]。
Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) (200 μg，腹腔注射，在第 0、5 和 10 天) 显著降低了 IL-23 诱导的关节炎的雄性 B10.RII 小鼠的关节炎发病率[2]。
Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) (200 μg，腹腔注射，每周两次，持续 4 周) 可以耗竭携带 MMC 肿瘤的 neu 转基因小鼠的 γδ T 细胞[3]。
Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) (500 µg，腹腔注射，单次剂量，第 -3 天) 显著抑制了患有移植物抗宿主病 (GVHD) 模型的雌性 BDF1 小鼠的 T 细胞浸润[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 1000 PFU JHM virus injected TCRβ-/- mice[1]
Dosage: 250 μg
Administration: Intraperitoneal injection (i.p.), on day 0, 3, 6, 9 and 12
Result: Significantly reduced the number of gamma delta T cells.
Reduced the degree of demyelination by 73 %.
Significantly improved clinical scores without limb paralysis.
Animal Model: IL-23 induced male B10.RIII mice (12-14 weeks)[2]
Dosage: 200 μg
Administration: Intraperitoneal injection (i.p.), on day 0, 5 and 10
Result: Significantly reduced the incidence rate of arthritis to 46.15 % (80 % in the control group) and reduced the disease severity score.
Reduced the accumulation of neutrophils in the blood, spleen, bone marrow, and joints.
Significantly reduced serum IL-17A levels and increased IL-27 p28 levels.
Reduced synovial hyperplasia in joints.
Animal Model: 1×106 MMC cells injected neu-transgenic mice[3]
Dosage: 200 μg, combined with PSK (100 mg/kg)
Administration: Intraperitoneal injection (i.p.), twice weekly for 4 weeks
Result: Significantly weakened the anti-tumor effect of PSK and increased tumor volume.
Animal Model: 2×108 splenocytes of B6 mice injected female BDF1 mice (8-10 weeks)[4]
Dosage: 500 µg
Administration: Intraperitoneal injection (i.p.), single dose, on day -3
Result: Significantly inhibited the infiltration of donor derived T cells into intestinal epithelium to 32 %.
Significantly reduced the mitotic index (MI) and apoptosis index (AI) of crypt cells.
Significantly reduced intestinal lesions.
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: ≥95.0%

COA (268 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse TCR gamma/delta Antibody (UC7-13D5)CD3Cluster of differentiation 3TCR gamma/deltaT cellsarthritisJHMMMCtransplantsGVHDInhibitorinhibitorinhibit

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