Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) 

Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) is a rat-derived IgG1 antibody inhibitor, targeting to TNF-alpha/TNFSF2. Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) neutralizes of TNF-alpha. Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) can be used for the researches of cancer, infection and immunology, such as dengue virus and B16K1 tumor^{[1][2][3][4][5]}.

Rat IgG1

Rat IgG1 kappa, Isotype Control

Mouse

TNF-alpha/TNFSF2

Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) 可中和内毒素诱导的小鼠胚胎成纤维细胞产生的肿瘤坏死因子^[3]。
Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) (10-1000 ng/mL, 7 days) 可减少 RAW264.7 细胞中分化的破骨细胞数量^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) (10 μg，静脉注射，单剂量) 可降低 Delta P80 病毒感染小鼠模型的肺部 TNF-α 水平并提高小鼠存活率^[1]。
Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) (100 μg，腹腔注射，在第 1、2、3 天给药) 可降低寨卡病毒免疫母亲所生小鼠中登革热病毒 2 (dengue virus 2) 诱导的致死率^[2]。
Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) (10 mg/kg，腹腔注射，在第 6、10、13、16 天给药) 可抑制 B16K1 肿瘤模型小鼠的肿瘤生长并克服对抗 PD-1 的耐药性^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

21926  [NCBI]

P06804

ELISA, FACS, Functional assay, Research in vivo

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

液体

Colorless to light yellow

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kobayashi M, et al. TNF-α exacerbates SARS-CoV-2 infection by stimulating CXCL1 production from macrophages. PLoS Pathog. 2024 Dec 9;20(12):e1012776.  [Content Brief]

  [2]. Fowler AM, T et al. Maternally Acquired Zika Antibodies Enhance Dengue Disease Severity in Mice. Cell Host Microbe. 2018 Nov 14;24(5):743-750.e5.  [Content Brief]

  [3]. Havell EA, et al. Endotoxin-induced tumor necrosis factor alpha synthesis in murine embryo fibroblasts. Infect Immun. 1993 May;61(5):1630-5.  [Content Brief]

  [4]. Katsumata K, et al. Conferring extracellular matrix affinity enhances local therapeutic efficacy of anti-TNF-α antibody in a murine model of rheumatoid arthritis. Arthritis Res Ther. 2019 Dec 23;21(1):298.  [Content Brief]

  [5]. Bertrand F, et al. TNFα blockade overcomes resistance to anti-PD-1 in experimental melanoma. Nat Commun. 2017 Dec 22;8(1):2256.  [Content Brief]