2. Immunology/Inflammation
  3. Interleukin Related
  4. Anti-Mouse TSLP Antibody (28F12)

Anti-Mouse TSLP Antibody (28F12) 

目录号: HY-P990150 纯度: 95.00%
COA 技术支持

Anti-Mouse TSLP Antibody (28F12) 是一种抗小鼠 TSLP IgG2a 单克隆抗体。Anti-Mouse TSLP Antibody (28F12) 通过减少 Treg 细胞和淋巴结细胞来减轻皮肤炎症和过敏反应。Anti-Mouse TSLP Antibody (28F12) 可用于过敏性疾病的研究。

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规格 价格 是否有货 数量
1 mg ￥2100
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5 mg ￥5900
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10 mg ￥9500
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Anti-Mouse TSLP Antibody (28F12) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse TSLP Antibody (28F12) is an anti-mouse TSLP IgG2a monoclonal antibody. Anti-Mouse TSLP Antibody (28F12) weakens skin inflammation and allergic reactions by reducing Treg cells and lymph node cells. Anti-Mouse TSLP Antibody (28F12) can be used for research on allergic conditions[1][2][3].

同型

Rat IgG2a kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

TSLP
体外研究
(In Vitro)

Anti-Mouse TSLP Antibody (28F12) (1 μg/mL) 抑制 NAG8/7 细胞中 TSLP 依赖性增殖[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse TSLP Antibody (28F12) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse TSLP Antibody (28F12) (200-400 μg，腹腔注射，每 3 天一次，持续 7 天) 显著减少了 Triclosan (HY-B1119) 诱导的雌性 BALB/c 小鼠的皮肤炎症并增加了淋巴结细胞[1]。
Anti-Mouse TSLP Antibody (28F12) (200 μg，腹腔注射，每周两次，持续 4 周) 显著抑制了 altered Schaedler flora (ASF) 定植的 C57BL/6 小鼠 Treg 细胞的扩增[2]。
Anti-Mouse TSLP Antibody (28F12) (250 μg，静脉注射，单次剂量，第 0 天) 显著抑制 papain (HY-P1645) 诱导的 BALB/c 或 C57BL/6 小鼠体内 Th2 分化，但不影响嗜酸性粒细胞或树突状细胞的迁移和成熟[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Triclosan induced female BALB/c mice (6-8 weeks)[1]
Dosage: 200-400 μg
Administration: Intraperitoneal injection (i.p.), once every 3 days, for 7 days
Result: Reduced the level of TSLP and IL-1β.
Reduced the numbers of B cells and dendritic cells (DCs).
Animal Model: C57BL/6 mice with an ASF colonization[2]
Dosage: 200 μg
Administration: Intraperitoneal injection (i.p.), twice a week, for 4 weeks
Result: Reduced the number of Treg cells.
Exacerbated Th17 and IFNγ responses.
Animal Model: Papain (50 μg) induced BALB/c or C57BL/6 mice[3]
Dosage: 250 μg
Administration: Intravenous injection (i.v.), single dose on day 0
Result: Significantly inhibited Th2 differentiation.
基因 ID

53603  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
  • Immobilized TSLP Protein, Mouse (HEK293, Fc, HY-P70626) can bind Anti-Mouse TSLP Antibody (28F12). The EC50 for this effect is 8.511 ng/mL.
纯度 & 产品资料

纯度: 95.00%

COA (266 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse TSLP Antibody (28F12) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse TSLP Antibody (28F12)Interleukin RelatedILTSLPTregimmunologyallergicInhibitorinhibitorinhibit

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